Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13191 / CBLB_HUMAN
Protein Name E3 ubiquitin-protein ligase CBL-B
Gene Name Name: CBLB
Synonyms:RNF56;ORFNames:Nbla00127;
Organism Homo sapiens (Human)

PRO ID PR:Q13191
DAG View
PRO Name E3 ubiquitin-protein ligase CBL-B (human)
Definition An E3 ubiquitin-protein ligase CBL-B that is encoded in the genome of human.
Short Label hCBLB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13191 (CBLB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R8 Methylation PhosphoSitePlus
R13 Methylation PhosphoSitePlus
R18 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S282 Phosphorylation Q04759 (PRKCQ) neXtProt   PhosphoSitePlus   UniProt 19549985
Y337 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus   RLIMS-P 23851457
Y363 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22158902, 20525694, 23851457
T471 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus   RLIMS-P 29109121
T479 Phosphorylation PhosphoSitePlus
S480 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 29109121, 17081983
S483 Phosphorylation PhosphoSitePlus
S484 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K491 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
S521 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S525 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T527 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S529 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K531 Ubiquitination PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
T620 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
Y665 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 10022120, 12842890
S672 Phosphorylation PhosphoSitePlus
T678 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
T698 Phosphorylation PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 12842890, 10022120
S735 Phosphorylation PhosphoSitePlus
Y763 Phosphorylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus
Y802 Phosphorylation PhosphoSitePlus
K837 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus
T885 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
Y889 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S894 Phosphorylation PhosphoSitePlus
S896 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S476 Phosphorylation HPRD 19651622
S480 Phosphorylation HPRD 19651622, 17081983
S483 Phosphorylation HPRD 19651622
S484 Phosphorylation HPRD 19651622, 17081983
S521 Phosphorylation HPRD 18669648
S525 Phosphorylation HPRD 18669648
T527 Phosphorylation HPRD 18669648
S529 Phosphorylation HPRD 18669648
S614 Phosphorylation HPRD 18691976
T678 Phosphorylation HPRD 18452278
T679 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R13 G13 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R18 Q18 Biomuta DOID:363 / uterine cancer [ tcga ]
Y106 * Biomuta DOID:3571 / liver cancer [ icgc ]
S282 I282 Biomuta DOID:363 / uterine cancer [ tcga ]
T479 K479 Biomuta DOID:3571 / liver cancer [ icgc ]
S483 C483 Biomuta DOID:1324 / lung cancer [ tcga ]
T527 K527 Biomuta DOID:3571 / liver cancer [ icgc ]
Y665 C665 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T679 I679 Biomuta DOID:363 / uterine cancer [ tcga ]
Y709 C709 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T882 S882 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y889 C889 Biomuta DOID:1324 / lung cancer [ cosmic ]
S977 P977 Biomuta DOID:9256 / colorectal cancer [ icgc ]