iPTMnet Report for Q13188 (STK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13188 / STK3_HUMAN
Protein Name Serine/threonine-protein kinase 3
Gene Name Name: STK3
Synonyms:KRS1,MST2;
Organism Homo sapiens (Human)

PRO ID PR:Q13188
DAG View
PRO Name serine/threonine-protein kinase 3 (human)
Definition A serine/threonine-protein kinase 3 that is encoded in the genome of human.
Short Label hSTK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13188 (STK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K13 Ubiquitination PhosphoSitePlus
S15 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 23904266, 19369195, 21723128
S15 Phosphorylation P53350 (PLK1) neXtProt 21723128
S18 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23904266, 21723128
S18 Phosphorylation P53350 (PLK1) neXtProt 21723128
K21 Ubiquitination PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 22590567
Y81 Phosphorylation P00519 (ABL1) PhosphoSitePlus   Signor 22590567
K116 Ubiquitination PhosphoSitePlus
T117 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20231902, 20086174
T117 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 20231902, 20086174
T117 Phosphorylation P31751 (AKT2) Signor 20231902
T117 Phosphorylation Q9Y243 (AKT3) Signor 20231902
K128 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
T180 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 22075148, 20231902, 24992339, ...12554736, 32292165, 30622739, 29063833
T180 Phosphorylation Q13188 (STK3) neXtProt   PhosphoSitePlus   Signor 20231902
T180 Phosphorylation Q7L7X3 (TAOK1) neXtProt 22075148
T235 Phosphorylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S316 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23904266, 18691976, 21406692, ...23186163, 17081983, 19369195, 21723128, 18669648, 19690332
S316 Phosphorylation P53350 (PLK1) neXtProt 21723128
S323 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus   RLIMS-P 29063833
S333 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19369195, 29063833, 23186163
S369 Phosphorylation PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus   RLIMS-P 29063833, 28373298, 26108669
T378 Phosphorylation Q13188 (STK3) PhosphoSitePlus 26108669
T384 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 20086174
T384 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 20086174
S385 Phosphorylation PhosphoSitePlus   RLIMS-P+   UniProt 27566175, 23186163
S385 Phosphorylation P06493 (CDK1) RLIMS-P+ 27566175
S392 Phosphorylation PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
C410 S-Nitrosylation dbSNO 26338901
K430 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
K453 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 18691976
T180 Phosphorylation HPRD   PRO 11278283, 12554736
T180 Phosphorylation Q13188 (STK3) HPRD 12554736
S316 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18452278
T325 Phosphorylation HPRD 18691976, 18452278
T384 Phosphorylation HPRD 18691976, 18669648
S385 Phosphorylation HPRD 19651622, 18691976, 20068231
S444 Phosphorylation HPRD 18691976


Q13188 (STK3) as PTM Enzyme



Substrate Site Score Source PMID
O95835 (LATS1) S872 neXtProt   PhosphoSitePlus 15688006
O95835 (LATS1) S909 neXtProt   PhosphoSitePlus   Signor 15688006
O95835 (LATS1) T967 neXtProt   PhosphoSitePlus 15688006
O95835 (LATS1) T1012 neXtProt   PhosphoSitePlus 15688006
O95835 (LATS1) T1060 neXtProt   PhosphoSitePlus 15688006
O95835 (LATS1) T1079 neXtProt   PhosphoSitePlus   Signor 15688006, 26108669
P00519 (ABL1) T735 neXtProt   PhosphoSitePlus   Signor 18794806
P17252 (PRKCA) S226 PhosphoSitePlus 26414765
P17252 (PRKCA) T228 PhosphoSitePlus 26414765
P18754 (RCC1) S2 neXtProt   Signor 19559616
P18754 (RCC1) S11 neXtProt   Signor 19559616
P46937 (YAP1) S127 PhosphoSitePlus 18640976
P51955 (NEK2) S356 neXtProt   PhosphoSitePlus 21076410
P51955 (NEK2) S365 neXtProt   PhosphoSitePlus 21076410
P51955 (NEK2) S406 neXtProt   PhosphoSitePlus 21076410
P51955 (NEK2) S438 neXtProt   PhosphoSitePlus   Signor 21076410
Q13188 (STK3) T180 HPRD   neXtProt   PhosphoSitePlus   Signor 20231902, 12554736
Q13188 (STK3) T378 PhosphoSitePlus 26108669
Q7L9L4 (MOB1B) T12 neXtProt   PhosphoSitePlus   Signor 21808241, 19919647, 18328708, ...19878874, 23431053
Q7L9L4 (MOB1B) T35 neXtProt   PhosphoSitePlus   Signor 21808241, 19919647, 18328708, ...19878874, 23431053
Q7L9L4 (MOB1B) T74 neXtProt   PhosphoSitePlus 19919647, 19878874
Q9H492 (MAP1LC3A) T50 RLIMS-P+ 25544559
Q9H4B6 (SAV1) T26 PhosphoSitePlus 21944251
Q9H4B6 (SAV1) S27 PhosphoSitePlus 21944251
Q9H4B6 (SAV1) S36 PhosphoSitePlus 21944251
Q9H4B6 (SAV1) S269 PhosphoSitePlus 21944251
Q9H8S9 (MOB1A) T12 PhosphoSitePlus   Signor 21808241, 26108669, 23431053
Q9H8S9 (MOB1A) T35 PhosphoSitePlus   Signor 21808241, 26108669, 23431053
Q9H8S9 (MOB1A) T74 PhosphoSitePlus   Signor 18362890
Q9NRM7 (LATS2) S872 Signor 21808241, 23431053
Q9NRM7 (LATS2) T1041 neXtProt   RLIMS-P+   Signor 26898830, 21808241, 23431053, ...21832154


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049368 (hSTK3/Phos:2) pT180 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04049 (RAF1) S259 Q13188 (STK3) increased_association eFIP 27527217
Phosphorylation Q13188 (STK3) T180 Q14BN4 (SLMAP) unknown eFIP 29063833
Phosphorylation Q13188 (STK3) Y81 P04049 (RAF1) unknown eFIP 22590567


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 C18 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K47 T47 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y81 H81 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T180 I180 Biomuta DOID:1319 / brain cancer [ icgc ]
S316 L316 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S316 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T378 A378 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]