iPTMnet Report for Q13177 (PAK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13177 / PAK2_HUMAN
Protein Name Serine/threonine-protein kinase PAK 2
Gene Name Name: PAK2
Organism Homo sapiens (Human)

PRO ID PR:Q13177
DAG View
PRO Name serine/threonine-protein kinase PAK 2 (human)
Definition A serine/threonine-protein kinase PAK 2 that is encoded in the genome of human.
Short Label hPAK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13177 (PAK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692, 22814378, 22223895, ...20068231
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20058876, 19651622, 20068231
S19 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   PRO   PhosphoSitePlus 10075701
S20 Phosphorylation P54646 (PRKAA2) , Q13177 (PAK2) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 22137581, 23171552, ...14500679, 29335522, 10075701
T21 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S55 Phosphorylation Q13177 (PAK2) HPRD   IEDB   neXtProt   PRO   PhosphoSitePlus   UniProt 23186163, 10075701, 27869121
S58 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 23186163, ...20068231
T60 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18088087, 18212344, ...20068231
K62 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus   UniProt 23186163
S75 Phosphorylation PhosphoSitePlus
N110 N-Glycosylation GlyGen 24190977
T112 Phosphorylation HPRD 20068231
K113 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus   UniProt 19608861
K128 Ubiquitination PhosphoSitePlus
Y130 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 29987050, 12215529
S132 Phosphorylation PhosphoSitePlus
T134 Phosphorylation Q9NYV4 (CDK12) PhosphoSitePlus   Signor   UniProt 32483448, 23186163
K136 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29987050, 24275569
S141 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16964243, 29335522, 16204230, ...21406692, 23186163, 18212344, 23171552, 14500679, 24275569, 23828041, 33693784, 10075701, 19413330, 18767875, 20058876, 19651622, 33464167, 17081983, 19664994, 19664995, 19690332, 18669648, 20166139, 29987050, 19415658, 20068231
T143 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 20166139, 23186163, ...17081983
K147 Ubiquitination PhosphoSitePlus
S152 Phosphorylation HPRD   PhosphoSitePlus 19664994
T154 Phosphorylation PhosphoSitePlus   UniProt 23186163
T169 O-Glycosylation GlyGen 29351928, 34019948, 28510447, ...30397120
T169 Phosphorylation Q9NYV4 (CDK12) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 32483448, ...19651622, 18669648
T178 O-Glycosylation GlyGen 29351928, 34019948, 28510447, ...30397120
K191 Ubiquitination PhosphoSitePlus
S192 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P 10075701, 14500679, 29335522
Y194 Phosphorylation PhosphoSitePlus   RLIMS-P 29987050
T195 Phosphorylation PhosphoSitePlus
S197 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18212344, 14500679, ...19690332, 29335522, 10075701, 20068231
G213 Myristoylation UniProt 16617111
K216 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
T228 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
C349 Methylation IEDB 31844290
K370 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
K399 Acetylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
S401 Phosphorylation HPRD   PhosphoSitePlus 20068231
T402 Phosphorylation Q13177 (PAK2) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 21098037, 16837009, 9786869, ...9693111, 14500679, 17254971, 12907671, 16204230, 11342659, 23828041, 18176785, 10075701, 20068231
T406 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K492 Acetylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K501 Acetylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S507 Phosphorylation HPRD   PhosphoSitePlus 20068231
S522 Phosphorylation HPRD 20068231


Q13177 (PAK2) as PTM Enzyme



Substrate Site Score Source PMID
P00519 (ABL1) S618 neXtProt   PhosphoSitePlus   Signor 18161990
P00519 (ABL1) S619 neXtProt   PhosphoSitePlus   Signor 18161990
P01106 (MYC) T358 neXtProt 14749374
P01236 (PRL) S179 neXtProt 11943200
P01236 (PRL) S207 phospho.ELM   Signor 11943200, 19555049
P05412 (JUN) T2 neXtProt   PhosphoSitePlus   Signor 21177766
P05412 (JUN) T8 neXtProt   PhosphoSitePlus   Signor 21177766
P05412 (JUN) T89 neXtProt   PhosphoSitePlus   Signor 21177766
P05412 (JUN) T93 neXtProt   PhosphoSitePlus   Signor 21177766
P05412 (JUN) T286 neXtProt   PhosphoSitePlus   Signor 21177766
P08670 (VIM) S26 HPRD 11895474, 2500966, 17287340, ...20068231
P08670 (VIM) S39 HPRD 17287340, 18767875, 20058876, ...19691289, 19007248, 18669648, 11895474, 2500966, 20068231
P08670 (VIM) S51 HPRD 19664995, 18212344, 19007248, ...19691289, 18669648, 11895474, 20068231
P08670 (VIM) S66 HPRD 11895474, 18669648, 20068231
P08670 (VIM) S73 HPRD 18578522, 19007248, 19651622, ...18669648, 20166139, 11895474, 20068231
P17600-2 (SYN1) S9 HPRD 12237306, 10571231
P19105 (MYL12A) S19 neXtProt 10047984
P24844 (MYL9) S20 phospho.ELM 10047984
P31152 (MAPK4) S186 neXtProt 21177870
P35240 (NF2) S518 phospho.ELM   PhosphoSitePlus   Signor 18071304, 11782491, 15378014
P49023 (PXN) S272 PhosphoSitePlus 23317503
P49023 (PXN) S274 PhosphoSitePlus 23317503
P55210 (CASP7) S30 neXtProt   PhosphoSitePlus   Signor 21555521
P55210 (CASP7) T173 neXtProt   PhosphoSitePlus   Signor 21555521
P55210 (CASP7) S239 neXtProt   PhosphoSitePlus   Signor 21555521
P62753 (RPS6) S235 HPRD 17322306, 18767875, 18669648, ...17287340
P62753 (RPS6) S236 HPRD 17322306, 18767875, 18669648, ...17287340
P62753 (RPS6) S240 HPRD 17322306, 18669648, 17287340, ...19007248
P62753 (RPS6) S242 HPRD 18669648, 1985906
P62805 (H4C16) S48 neXtProt 21724829
Q04637 (EIF4G1) S895 PhosphoSitePlus 16281055
Q05682 (CALD1) S714 PhosphoSitePlus 16800003
Q05682 (CALD1) S744 PhosphoSitePlus 16800003
Q13177 (PAK2) S19 HPRD   neXtProt 10075701
Q13177 (PAK2) S20 HPRD   neXtProt 10075701
Q13177 (PAK2) S55 HPRD   neXtProt 10075701
Q13177 (PAK2) S141 HPRD   neXtProt   Signor 19413330, 18212344, 18767875, ...20058876, 19664995, 19415658, 19651622, 19664994, 18669648, 16204230, 20166139, 10075701, 20068231, 16964243
Q13177 (PAK2) S192 HPRD   neXtProt 10075701
Q13177 (PAK2) S197 HPRD   neXtProt 10075701, 20068231, 18212344
Q13177 (PAK2) T402 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+   UniProt 21098037, 16837009, 9786869, ...9693111, 12907671, 16204230, 17254971, 18176785, 10075701, 20068231
Q15746 (MYLK) S1208 HPRD   neXtProt 10748018
Q15746 (MYLK) S1759 neXtProt 10748018
Q15746-1 (MYLK) S1760 HPRD 10748018, 18088087, 2160950
Q15796 (SMAD2) S417 PhosphoSitePlus 22393057
Q16659 (MAPK6) S189 neXtProt   PhosphoSitePlus 21317288, 21177870
Q70Z35 (PREX2) S1107 PhosphoSitePlus 26438819
Q9BUB5 (MKNK1) S39 HPRD   neXtProt   Signor 15234964


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048690 (hPAK2/InitMet-/Phos:2) pS19,pS20,pS55,pS192,pS197 PRO
PR:000048691 (hPAK2/Phos:3) pS141,pT402 PRO
PR:000048692 (hPAK2/Phos:4) pY130,pS141,pT402 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S20 R20 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T25 A25 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S42 C42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S58 L58 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T112 I112 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
K128 R128 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K128 N128 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y130 N130 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y139 N139 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y139 C139 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S141 G141 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S141 I141 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S152 C152 Biomuta DOID:184 / bone cancer [ cosmic ]
T154 R154 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S217 Y217 Biomuta DOID:363 / uterine cancer [ icgc ]
S217 C217 Biomuta DOID:184 / bone cancer [ cosmic ]
Y453 H453 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K468 T468 Biomuta DOID:3571 / liver cancer [ cosmic ]
S490 L490 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]