iPTMnet Report for Q13164 (MAPK7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13164 / MK07_HUMAN
Protein Name Mitogen-activated protein kinase 7
Gene Name Name: MAPK7
Synonyms:BMK1,ERK5,PRKM7;
Organism Homo sapiens (Human)

PRO ID PR:Q13164
DAG View
PRO Name mitogen-activated protein kinase 7 (human)
Definition A mitogen-activated protein kinase 7 that is encoded in the genome of human.
Short Label hMAPK7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13164 (MAPK7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Sumoylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K22 Sumoylation PhosphoSitePlus
T28 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus 12628002
S31 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
T219 Phosphorylation Q13163 (MAP2K5) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 20667468, 12628002
Y221 Phosphorylation Q13163 (MAP2K5) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 20667468, 12628002
T224 Phosphorylation PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
S421 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus 12628002
S433 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus 12628002
S472 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K480 Methylation PhosphoSitePlus
K485 Methylation PhosphoSitePlus
S486 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   RLIMS-P 14679215, 20538799
S496 Phosphorylation Q13164 (MAPK7) , Q15418 (RPS6KA1) neXtProt   PhosphoSitePlus   RLIMS-P 30238007, 29594152, 35801078, ...22267842, 12628002
S562 Phosphorylation PhosphoSitePlus
S567 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus   Signor 20667468
T584 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus   UniProt 18669648
S731 Phosphorylation Q13164 (MAPK7) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 30132833, 12628002, 20667468
T733 Phosphorylation Q13164 (MAPK7) , P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32170057, 25689862, 20667468, ...18669648, 12628002
S754 Phosphorylation PhosphoSitePlus   RLIMS-P 32170057
S770 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus 25689862
S772 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus 25689862
S774 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus 25689862
S776 Phosphorylation PhosphoSitePlus
S803 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus   Signor 20667468
Site PTM Type PTM Enzyme Score Source PMID
T28 Phosphorylation PR:000048327 (hMAPK7/InitMet-/Phos:2) PRO 20832753, 12628002
T219 Phosphorylation HPRD   PRO 11739740, 20832753, 12628002
Y221 Phosphorylation HPRD   PRO 11739740, 20832753, 12628002
S421 Phosphorylation PR:000048327 (hMAPK7/InitMet-/Phos:2) PRO 20832753, 12628002
S433 Phosphorylation PR:000048327 (hMAPK7/InitMet-/Phos:2) PRO 20832753, 12628002
S496 Phosphorylation PR:000048327 (hMAPK7/InitMet-/Phos:2) PRO 20832753, 12628002
T584 Phosphorylation HPRD 20058876
S720 Phosphorylation HPRD 18669648
S731 Phosphorylation PR:000048327 (hMAPK7/InitMet-/Phos:2) HPRD   PRO 19651622, 18669648, 20832753, ...12628002
T733 Phosphorylation PR:000048327 (hMAPK7/InitMet-/Phos:2) HPRD   PRO 19651622, 20832753, 18669648, ...19664994, 12628002
Site PTM Type PTM Enzyme Score Source PMID
T80 Phosphorylation HPRD 11739740
Y82 Phosphorylation HPRD 11739740
T445 Phosphorylation HPRD 20058876
S581 Phosphorylation HPRD 18669648
S592 Phosphorylation HPRD 19651622, 18669648
T594 Phosphorylation HPRD 19651622, 18669648, 19664994


Q13164 (MAPK7) as PTM Enzyme



Substrate Site Score Source PMID
O00141 (SGK1) S78 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11254654, 18691976
P01100 (FOS) S32 neXtProt   PhosphoSitePlus 17018293
P01100 (FOS) T232 neXtProt   PhosphoSitePlus 17018293
P14921 (ETS1) T38 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12048211, 11948414
P17302 (GJA1) S255 HPRD   neXtProt   Signor 19664994, 9535909, 12637502, ...8631994
P17302 (GJA1) S282 HPRD 9535905, 12637502, 8631994
P19793-1 (RXRA) T82 HPRD 12048211
P19793-1 (RXRA) S260 HPRD 12048211
P29590 (PML) S403 neXtProt   PhosphoSitePlus 20832753
P29590 (PML) T409 neXtProt   PhosphoSitePlus 20832753
Q02078-5 (MEF2A) T304 HPRD 10849446, 9858528
Q02078-5 (MEF2A) T311 HPRD 10849446, 9858528
Q02078 (MEF2A) T312 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10849446, 9858528
Q02078 (MEF2A) T319 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10849446, 9858528
Q02078-5 (MEF2A) S347 HPRD 10849446
Q02078 (MEF2A) S355 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10849446
Q06413-1 (MEF2C) S387 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9384584
Q12959 (DLG1) S158 PhosphoSitePlus 20643107
Q13163 (MAP2K5) S129 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
Q13163 (MAP2K5) S137 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
Q13163 (MAP2K5) S142 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
Q13163 (MAP2K5) S149 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
Q13164 (MAPK7) T28 neXtProt   PhosphoSitePlus 12628002
Q13164 (MAPK7) S421 neXtProt   PhosphoSitePlus 12628002
Q13164 (MAPK7) S433 neXtProt   PhosphoSitePlus 12628002
Q13164 (MAPK7) S496 neXtProt   PhosphoSitePlus 12628002
Q13164 (MAPK7) S567 Signor 20667468
Q13164 (MAPK7) S731 neXtProt   PhosphoSitePlus   Signor 20667468, 12628002
Q13164 (MAPK7) T733 neXtProt   PhosphoSitePlus   Signor 20667468, 25689862, 12628002
Q13164 (MAPK7) S770 PhosphoSitePlus 25689862
Q13164 (MAPK7) S772 PhosphoSitePlus 25689862
Q13164 (MAPK7) S774 PhosphoSitePlus 25689862
Q13164 (MAPK7) S803 Signor 20667468
Q14814 (MEF2D) S180 HPRD   neXtProt   Signor 18691976, 10849446, 18669648, ...20068231, 18767875
Q14934 (NFATC4) S168 neXtProt 18347059
Q14934 (NFATC4) S170 neXtProt 18347059
Q92886 (NEUROG1) S178 neXtProt 19365559
Q92886 (NEUROG1) S201 neXtProt 19365559
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026481 (hMAPK7/iso:1/Phos:1) pT28,pT219,pY221,pS421,pS433,pS496,pS731,pT733 PR:000048327 (hMAPK7/InitMet-/Phos:2) PRO 12628002, 20832753


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048327 (hMAPK7/InitMet-/Phos:2) pT219,pY221 PRO 12628002
PR:000026481 (hMAPK7/iso:1/Phos:1) pT219,pY221 PRO 12628002, 20832753
PR:000026481 (hMAPK7/iso:1/Phos:1) pT28,pS421,pS433,pS496,pS731,pT733 PR:000048327 (hMAPK7/InitMet-/Phos:2) PRO 12628002, 20832753


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026481 (hMAPK7/iso:1/Phos:1) Interaction PR:P29590-1 (hPML/iso:1) PRO 20832753
PR:P29590-1 (hPML/iso:1) Interaction PR:Q13164 (hMAPK7) PRO 20832753


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T28 I28 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y216 * Biomuta DOID:1319 / brain cancer [ cosmic ]
T224 M224 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S581 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T594 I594 Biomuta DOID:4159 / skin cancer [ cosmic ]
S718 F718 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S720 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T733 I733 Biomuta DOID:4159 / skin cancer [ cosmic ]
S803 Y803 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S803 F803 Biomuta DOID:1324 / lung cancer [ cosmic ]