iPTMnet Report for Q13163 (MAP2K5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13163 / MP2K5_HUMAN
Protein Name Dual specificity mitogen-activated protein kinase kinase 5
Gene Name Name: MAP2K5
Synonyms:MEK5,MKK5,PRKMK5;
Organism Homo sapiens (Human)

PRO ID PR:Q13163
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 5 (human)
Definition A dual specificity mitogen-activated protein kinase kinase 5 that is encoded in the genome of human.
Short Label hMAP2K5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13163 (MAP2K5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation IEDB 32387766
T71 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
R125 Methylation PhosphoSitePlus
S129 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12628002
S129 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
S133 Phosphorylation PhosphoSitePlus
S137 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12628002
S137 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
S142 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12628002
S142 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
K146 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S149 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12628002
S149 Phosphorylation Q13164 (MAPK7) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12628002
K154 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S311 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 7759517, 28639275
T315 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 7759517, 28639275
Site PTM Type PTM Enzyme Score Source PMID
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976
S142 Phosphorylation HPRD 18691976
S148 Phosphorylation HPRD 18691976
S311 Phosphorylation HPRD 7759517
T315 Phosphorylation HPRD 7759517
Site PTM Type PTM Enzyme Score Source PMID
S132 Phosphorylation HPRD 18691976
S133 Phosphorylation HPRD 18691976
S142 Phosphorylation HPRD 18691976
S148 Phosphorylation HPRD 18691976
S311 Phosphorylation HPRD 7759517
T315 Phosphorylation HPRD 7759517


Q13163 (MAP2K5) as PTM Enzyme



Substrate Site Score Source PMID
Q13164 (MAPK7) T219 PhosphoSitePlus   Signor 20667468, 12628002
Q13164 (MAPK7) Y221 PhosphoSitePlus   Signor 20667468, 12628002


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K121 N121 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R125 W125 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R125 Q125 Biomuta DOID:4159 / skin cancer [ cosmic ]
S132 N132 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S142 I142 Biomuta DOID:3571 / liver cancer [ cosmic ]
S149 P149 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S149 Y149 Biomuta DOID:1324 / lung cancer [ cosmic ]
K298 E298 Biomuta DOID:4159 / skin cancer [ cosmic ]
T315 M315 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, cosmic, cosmic ]