iPTMnet Report for Q13153 (PAK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13153 / PAK1_HUMAN
Protein Name Serine/threonine-protein kinase PAK 1
Gene Name Name: PAK1
Organism Homo sapiens (Human)

PRO ID PR:Q13153
DAG View
PRO Name serine/threonine-protein kinase PAK 1 (human)
Definition A serine/threonine-protein kinase PAK 1 that is encoded in the genome of human.
Short Label hPAK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13153 (PAK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation Q13153 (PAK1) , Q13976-2 (PRKG1) , P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 14585966, 16490784, 17989089, ...9032240
S28 Phosphorylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S38 Phosphorylation RLIMS-P 20621182
K39 Ubiquitination PhosphoSitePlus
S57 Phosphorylation Q13153 (PAK1) neXtProt   UniProt 9032240, 17989089
K63 Acetylation PhosphoSitePlus
S79 Phosphorylation RLIMS-P 23936510
T84 Phosphorylation O95747 (OXSR1) neXtProt   RLIMS-P   Signor 14707132
T109 Phosphorylation Q15831 (STK11) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20400510
S110 Phosphorylation PhosphoSitePlus
N111 N-Glycosylation GlyGen 24190977
S115 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y131 Phosphorylation PhosphoSitePlus   UniProt 17989089
S133 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus   UniProt 17989089
S144 Phosphorylation Q13153 (PAK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   UniProt 32186433, 21406692, 31748572, ...23936510, 20417602, 27885255, 23885116, 9032240, 26219339, 31781560, 31872963, 31660987
T146 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S149 Phosphorylation Q13153 (PAK1) neXtProt   PhosphoSitePlus   UniProt 21406692, 9032240
Y153 Phosphorylation O60674 (JAK2) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 27542844, 17989089, 25466889, ...17726028
S155 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S174 Phosphorylation Q9BWU1 (CDK19) PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 19520772, 17989089
T185 Phosphorylation PhosphoSitePlus   UniProt 17989089
T197 Phosphorylation PhosphoSitePlus
S199 Phosphorylation Q13153 (PAK1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 32186433, 23885116, 23936510, ...20417602, 9032240, 32752894
Y201 Phosphorylation O60674 (JAK2) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 27542844, 25466889, 17726028
S204 Phosphorylation Q13153 (PAK1) neXtProt   PhosphoSitePlus   UniProt 19690332, 9032240
T212 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11604394, 28393858, 15542607, ...16964243, 19298660, 25174975, 17989089, 18669648, 23260667, 23734197, 12176334, 19690332, 12176333
T214 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus   UniProt 19690332
S220 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S223 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23885116, 18669648, 21406692, ...26160174
T225 Phosphorylation PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
T230 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
T236 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
K256 Sumoylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation O60674 (JAK2) neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 27542844, 17989089, 25466889, ...17726028
T292 Phosphorylation P27361 (MAPK3) Signor 14993270
K309 Ubiquitination PhosphoSitePlus
C373 Methylation IEDB 31844290
K391 Ubiquitination PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
T423 Phosphorylation O15530 (PDPK1) , Q8IWQ3 (BRSK2) , Q13153 (PAK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 28393858, 23885116, 22669945, ...23936510, 32322465, 16990256, 9032240, 30971268, 15713627, 9525917, 22369945, 21209852, 15893667, 10995762, 17254971, 32186433, 19812368, 22719252, 26379399, 33928090, 25174975, 27126178, 11134074, 19298660, 22491145, 30651600, 18459146, 22153498, 31872963, 10551809
T427 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
K513 Acetylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation Q13153 (PAK1) HPRD 10805734, 9032240
S57 Phosphorylation Q13153 (PAK1) HPRD 9032240
T84 Phosphorylation O95747 (OXSR1) HPRD 14707132
S144 Phosphorylation Q13153 (PAK1) HPRD 11278486, 19664994, 9032240, ...20068231
S149 Phosphorylation Q13153 (PAK1) HPRD 11278486, 9032240
S165 Phosphorylation Q13153 (PAK1) HPRD 16204230
S174 Phosphorylation HPRD 19651622
S199 Phosphorylation Q13153 (PAK1) HPRD 9032240
S204 Phosphorylation Q13153 (PAK1) HPRD 19664994, 9032240
T212 Phosphorylation Q00535 (CDK5) HPRD 11604394, 19413330, 19664994, ...19664995, 20058876
S220 Phosphorylation HPRD 15345747
S223 Phosphorylation HPRD 15345747, 19664995
T225 Phosphorylation HPRD 19413330
T229 Phosphorylation HPRD 19413330, 19664995
T230 Phosphorylation HPRD 19413330, 18669648, 19664995
T423 Phosphorylation O15530 (PDPK1) HPRD 10995762


Q13153 (PAK1) as PTM Enzyme



Substrate Site Score Source PMID
O14965 (AURKA) T288 neXtProt   PhosphoSitePlus   Signor 24867643, 16246726
O14965 (AURKA) S342 neXtProt   PhosphoSitePlus 16246726
O15143 (ARPC1B) T21 HPRD   neXtProt   PhosphoSitePlus   Signor 14749719
O95863 (SNAI1) S246 phospho.ELM   PhosphoSitePlus   Signor 15833848, 25125660
P03372 (ESR1) S305 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12374744
P04049 (RAF1) S338 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15849194, 11274179, 9823899, ...11733498, 11948406, 12551923, 10801448, 9234708, 17428866, 18775988, 10205168, 11376654
P04049 (RAF1) S339 phospho.ELM   PhosphoSitePlus   Signor 15849194, 18775988
P08670 (VIM) S26 neXtProt 11895474
P08670 (VIM) S39 neXtProt 11895474
P08670 (VIM) S51 neXtProt 11895474
P08670 (VIM) S56 PhosphoSitePlus   Signor 16997882, 15766329, 16990256
P08670 (VIM) S66 neXtProt 11895474
P08670 (VIM) S73 neXtProt 11895474
P10398 (ARAF) S299 Signor 15710605
P15056 (BRAF) S446 phospho.ELM   PhosphoSitePlus 15710605
P16949 (STMN1) S16 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11058583, 7925472, 14645234
P16949 (STMN1) S38 PhosphoSitePlus   Signor 10913145, 19162178
P17600-1 (SYN1) S605 HPRD 12237306
P18669 (PGAM1) S23 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12189148
P18669 (PGAM1) S118 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12189148
P19086 (GNAZ) S16 phospho.ELM   PhosphoSitePlus   Signor 9166747, 10531372
P21333 (FLNA) S2152 phospho.ELM   PhosphoSitePlus   Signor 12198493, 23340249
P21333 (FLNA) S2292 PhosphoSitePlus 12198493
P21333 (FLNA) S2370 PhosphoSitePlus 12198493
P24844 (MYL9) S20 PhosphoSitePlus 18854160
P29466-1 (CASP1) S376 HPRD 15561713
P31749 (AKT1) S473 RLIMS-P+ 18054038
P35222 (CTNNB1) S675 PhosphoSitePlus   Signor 21822311
P35240-4 (NF2) S435 HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
P35240-6 (NF2) S476 HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
P35240-5 (NF2) S477 HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
P35240 (NF2) S518 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 11719502, 11782491, 18071304, ...19691289, 19651622, 18669648, 27285107, 20068231
P36871 (PGM1) T467 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15378030
P42229 (STAT5A) S780 neXtProt 12732616
P46108 (CRK) S41 PhosphoSitePlus 22848689
P49023 (PXN) S258 PhosphoSitePlus 23317503
P49023 (PXN) S272 PhosphoSitePlus   Signor 16717130
P51114 (FXR1) S420 PhosphoSitePlus 20417602
P52565 (ARHGDIA) S101 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15225553
P52565 (ARHGDIA) S174 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15225553
P53350 (PLK1) S49 neXtProt   PhosphoSitePlus   Signor 18427546
P53667-1 (LIMK1) T508 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11340065, 10559936, 10652353
P58012 (FOXL2) S263 HPRD   phospho.ELM 12560069
P63167 (DYNLL1) S88 neXtProt   PhosphoSitePlus   Signor 18084006, 15193260
P68431 (H3C12) S11 Signor 12151336
P78545 (ELF3) S207 neXtProt   PhosphoSitePlus   Signor 17491012
Q02750 (MAP2K1) S298 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 16129686, 11948406, 9351825, ...12876277, 18593598, 14993270
Q12778 (FOXO1) S256 HPRD 10358014, 12560069
Q13153 (PAK1) S21 HPRD   neXtProt   UniProt 14585966, 9032240, 10805734
Q13153 (PAK1) S57 HPRD   neXtProt   UniProt 9032240, 17989089
Q13153 (PAK1) S144 HPRD   neXtProt   PhosphoSitePlus   UniProt 20068231, 11278486, 19664994, ...9032240, 20417602
Q13153-1 (PAK1) S149 HPRD   neXtProt 11278486, 9032240
Q13153-1 (PAK1) S165 HPRD 16204230
Q13153 (PAK1) S199 HPRD   neXtProt   PhosphoSitePlus   UniProt 9032240, 20417602
Q13153 (PAK1) S204 HPRD   neXtProt 19664994, 9032240
Q13153 (PAK1) T423 neXtProt   PhosphoSitePlus   UniProt 9525917, 17254971, 10995762, ...9032240, 10551809
Q13233 (MAP3K1) S67 neXtProt   PhosphoSitePlus   Signor 12228228
Q13352 (ITGB3BP) S28 PhosphoSitePlus   Signor 18521086
Q13363 (CTBP1) S158 neXtProt   PhosphoSitePlus   Signor 12872159
Q13418 (ILK) T173 neXtProt   PhosphoSitePlus   Signor 17420447
Q13418 (ILK) S246 neXtProt   PhosphoSitePlus   Signor 17420447
Q14155 (ARHGEF7) S518 neXtProt 17392278
Q14247 (CTTN) S405 PhosphoSitePlus   Signor 20444238, 21079800
Q14247 (CTTN) S418 PhosphoSitePlus   Signor 20444238, 21079800
Q15365 (PCBP1) T60 PhosphoSitePlus 17389360
Q15365 (PCBP1) T127 PhosphoSitePlus 17389360
Q15746-1 (MYLK) S18 HPRD 10092231
Q15746 (MYLK) S1772 PhosphoSitePlus 15310280
Q70Z35 (PREX2) S1107 PhosphoSitePlus 26438819
Q7Z628 (NET1) S152 neXtProt 15684429
Q8IYU2 (HACE1) S385 Signor 29362425
Q92934 (BAD) S74 neXtProt   PhosphoSitePlus   Signor 22096607
Q92934 (BAD) S75 PhosphoSitePlus   Signor 10611223
Q92934 (BAD) S99 phospho.ELM   PhosphoSitePlus   Signor 19667065, 10611223
Q92934 (BAD) S118 HPRD   PhosphoSitePlus 10949026, 18669648, 19667065, ...18707149, 20166139, 10837486
Q92934 (BAD) S134 HPRD   PhosphoSitePlus 20166139, 16413544, 21317286
Q92974-3 (ARHGEF2) S858 HPRD 14970201, 18669648
Q92974 (ARHGEF2) S886 HPRD   neXtProt   PhosphoSitePlus   Signor 14970201, 18669648, 19667072
Q96A00 (PPP1R14A) T38 neXtProt 12359219
Q96T58 (SPEN) S3486 neXtProt   PhosphoSitePlus 15824732
Q96T58 (SPEN) T3568 neXtProt   PhosphoSitePlus 15824732
Q99426 (TBCB) S65 PhosphoSitePlus   Signor 15831477
Q99426 (TBCB) S128 PhosphoSitePlus   Signor 15831477
Q99661 (KIF2C) S111 PhosphoSitePlus   Signor 23055517
Q99661 (KIF2C) S192 PhosphoSitePlus   Signor 23055517
Q9UQ80 (PA2G4) T261 PhosphoSitePlus   Signor 18283314
Q9Y2X7 (GIT1) S508 PhosphoSitePlus 16246726
Q9Y2X7 (GIT1) S700 PhosphoSitePlus 16797488
Q9Y6X9 (MORC2) S739 PhosphoSitePlus 25888627, 23260667
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000030192 (hCTNNB1/iso:1/Phos:1) pS663,pS675 PR:000035776 (hPAK1/Phos:1) PRO 22369945


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035776 (hPAK1/Phos:1) pT423 PRO 22369945
PR:000048687 (hPAK1/Phos:3) pS144 PRO
PR:000048688 (hPAK1/Phos:4) pS144,pT423 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T20 I20 Biomuta DOID:4159 / skin cancer [ cosmic ]
S28 N28 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S38 C38 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S79 L79 Biomuta DOID:4159 / skin cancer [ cosmic ]
N111 H111 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S115 L115 Biomuta DOID:1324 / lung cancer [ cosmic ]
S133 L133 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S133 P133 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y142 C142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S155 Y155 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T185 I185 Biomuta DOID:363 / uterine cancer [ icgc ]
Y201 C201 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T219 A219 Biomuta DOID:4159 / skin cancer [ cosmic ]
T229 A229 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T230 A230 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T230 I230 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C373 F373 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T415 N415 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y474 H474 Biomuta DOID:363 / uterine cancer [ icgc ]
Y474 C474 Biomuta DOID:363 / uterine cancer [ icgc ]
S491 L491 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K508 N508 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S511 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S511 L511 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S528 F528 Biomuta DOID:4159 / skin cancer [ cosmic ]