Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13144 / EI2BE_HUMAN
Protein Name Translation initiation factor eIF-2B subunit epsilon
Gene Name Name: EIF2B5
Synonyms:EIF2BE;
Organism Homo sapiens (Human)

PRO ID PR:Q13144
DAG View
PRO Name translation initiation factor eIF-2B subunit epsilon (human)
Definition A translation initiation factor eIF-2B subunit epsilon that is encoded in the genome of human.
Short Label hEIF2B5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13144 (EIF2B5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S20 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S51 Phosphorylation P48729 (CSNK1A1) HPRD 11500362
K61 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus   UniProt 24275569
S466 Phosphorylation P48729 (CSNK1A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11500362, 24275569
S469 Phosphorylation P48729 (CSNK1A1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11500362, 24275569
K481 Ubiquitination PhosphoSitePlus
Y483 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
S525 Phosphorylation HPRD   PhosphoSitePlus 17081983
S527 Phosphorylation HPRD   PhosphoSitePlus 17081983
S529 Phosphorylation HPRD   PhosphoSitePlus 17081983
S532 Phosphorylation HPRD   PhosphoSitePlus 17081983
S535 Phosphorylation P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 12133000, 11311121
S540 Phosphorylation P49841 (GSK3B) , P49840 (GSK3A) HPRD   PhosphoSitePlus   Signor 18701453, 11500362, 9468292
S544 Phosphorylation P49840 (GSK3A) , P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 18088087, ...17081983, 19413330, 15302935, 16097034, 19007248, 18452278, 19651622, 19664994, 18669648, 24275569, 18707149, 20166139, 23186163, 11500362, 20068231
K565 Ubiquitination PhosphoSitePlus
Y583 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
C618 S-Nitrosylation dbSNO 19483679
K693 Ubiquitination PhosphoSitePlus
S717 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 11500362, 19690332
S718 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   Signor 18669648, 11500362


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S469 Y469 Biomuta DOID:363 / uterine cancer [ tcga ]
S529 T529 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S544 Y544 Biomuta DOID:363 / uterine cancer [ tcga ]