iPTMnet Report for Q13131 (PRKAA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13131 / AAPK1_HUMAN
Protein Name 5'-AMP-activated protein kinase catalytic subunit alpha-1
Gene Name Name: PRKAA1
Synonyms:AMPK1;
Organism Homo sapiens (Human)

PRO ID PR:Q13131
DAG View
PRO Name 5'-AMP-activated protein kinase catalytic subunit alpha-1 (human)
Definition A 5'-AMP-activated protein kinase catalytic subunit alpha-1 that is encoded in the genome of human.
Short Label hPRKAA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13131 (PRKAA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
K40 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S108 Phosphorylation RLIMS-P 19940154, 33658485
K118 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
T183 Phosphorylation Q8TDC3-2 (BRSK1) , Q16584 (MAP3K11) , Q15831 (STK11) , Q13554 (CAMK2B) , Q8N5S9 (CAMKK1) , Q13131 (PRKAA1) , Q96RR4 (CAMKK2) , Q8IWQ3 (BRSK2) neXtProt   PhosphoSitePlus   Signor 15980064, 18303014, 19376078, ...14985505, 21768291, 21680840, 14511394, 25874865, 16407220, 14614828, 23583109, 23625915, 21918180, 18854318
S184 Phosphorylation PhosphoSitePlus
C185 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S187 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
C321 Methylation IEDB 31844290
Y352 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus   UniProt 24275569
S356 Phosphorylation PhosphoSitePlus   UniProt 18669648
S360 Phosphorylation Q13131 (PRKAA1) , O75385 (ULK1) neXtProt   PhosphoSitePlus 21460634, 19376078
T368 Phosphorylation O75385 (ULK1) neXtProt 21460634
T382 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 18220336
T388 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19376078
K396 Ubiquitination PhosphoSitePlus
S397 Phosphorylation O75385 (ULK1) neXtProt   PhosphoSitePlus 21460634
K406 Sumoylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus   UniProt 19369195
T482 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S486 Phosphorylation P49841 (GSK3B) , O75385 (ULK1) , Q13131 (PRKAA1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   UniProt 19376078, 23186163, 17023420, ...18669648, 21460634, 23623684
T488 Phosphorylation O75385 (ULK1) neXtProt   PhosphoSitePlus 21460634
T490 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   UniProt 18669648, 23186163, 23623684
S494 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19376078
S496 Phosphorylation Q13131 (PRKAA1) , P31749 (AKT1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19376078, 23186163, 26640549, ...16340011, 18669648, 24275569, 27784766
S498 Phosphorylation PhosphoSitePlus
Y500 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus   UniProt 24275569
K515 Ubiquitination PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus   UniProt 24275569
T526 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus   UniProt 24275569
S531 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T183 Phosphorylation HPRD   PRO 8910387
S184 Phosphorylation HPRD 18669648
T355 Phosphorylation HPRD 18691976, 18669648
S356 Phosphorylation HPRD 18691976, 18669648, 20068231
T382 Phosphorylation HPRD 18669648
Y442 Phosphorylation HPRD 18083107
S476 Phosphorylation HPRD 18691976
T482 Phosphorylation HPRD 18669648
S486 Phosphorylation HPRD 18691976, 18669648
T488 Phosphorylation HPRD 18691976, 18669648
T490 Phosphorylation HPRD 18691976, 18669648
S496 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18088087, 20166139
S506 Phosphorylation HPRD 18691976
S508 Phosphorylation HPRD 18691976
S523 Phosphorylation HPRD 18691976
S527 Phosphorylation HPRD 18691976
S530 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
K130 Ubiquitination PhosphoSitePlus
T198 Phosphorylation HPRD 8910387
S199 Phosphorylation HPRD 18669648
T370 Phosphorylation HPRD 18691976, 18669648
S371 Phosphorylation HPRD 18691976, 18669648, 20068231
T397 Phosphorylation HPRD 18669648
Y457 Phosphorylation HPRD 18083107
S491 Phosphorylation HPRD 18691976
T497 Phosphorylation HPRD 18669648
S501 Phosphorylation HPRD 18691976, 18669648
T503 Phosphorylation HPRD 18691976, 18669648
T505 Phosphorylation HPRD 18691976, 18669648
S511 Phosphorylation HPRD 19651622, 18691976, 18669648, ...18088087, 20166139
S521 Phosphorylation HPRD 18691976
S523 Phosphorylation HPRD 18691976
S538 Phosphorylation HPRD 18691976
S542 Phosphorylation HPRD 18691976
S545 Phosphorylation HPRD 18691976


Q13131 (PRKAA1) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S78 HPRD 14709557, 15024086
O00418 (EEF2K) S366 HPRD 11500364, 14709557, 15024086, ...11171059
O00418 (EEF2K) S398 HPRD   neXtProt   PhosphoSitePlus   Signor 22669845, 14709557, 15024086
O00429 (DNM1L) S637 RLIMS-P+ 23979843
O00763 (ACACB) S222 PhosphoSitePlus 17276402
O15350 (TP73) S426 PhosphoSitePlus 24874608
O15360 (FANCA) S347 RLIMS-P+ 27449087
O43524 (FOXO3) T179 PhosphoSitePlus   Signor 17711846
O43524 (FOXO3) S399 PhosphoSitePlus   Signor 17711846
O43524 (FOXO3) S413 PhosphoSitePlus   Signor 17711846
O43524 (FOXO3) S555 PhosphoSitePlus   Signor 17711846
O43524 (FOXO3) S588 PhosphoSitePlus   Signor 17711846
O43524 (FOXO3) S626 PhosphoSitePlus   Signor 17711846
O60825-1 (PFKFB2) S466 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 11069105, 18767875, ...19651622, 18669648, 12853467, 20068231, 17924679
O75385 (ULK1) S317 neXtProt 21258367, 23372762
O75385 (ULK1) S638 PhosphoSitePlus 21383122
O75925 (PIAS1) S510 Signor 27256105
O95278 (EPM2A) S25 PhosphoSitePlus 21728993
O95863 (SNAI1) S92 Signor 19923321
P00533 (EGFR) T892 PhosphoSitePlus 26143491
P04049 (RAF1) S259 Signor 11971957
P04049-1 (RAF1) S621 HPRD   neXtProt   Signor 9710607, 11971957, 19007248, ...9091312, 19651622, 20166139, 20068231
P04406 (GAPDH) S122 PhosphoSitePlus 26626483
P04626 (ERBB2) T900 PhosphoSitePlus 26143491
P04637 (TP53) S15 Signor 15866171
P04637 (TP53) T18 PhosphoSitePlus 17339337
P04637 (TP53) S20 PhosphoSitePlus 17339337
P06400 (RB1) S811 Signor 19217427
P08151 (GLI1) S102 Signor 26190112
P08151 (GLI1) S408 Signor 26190112
P08151 (GLI1) T1074 Signor 26190112
P10636-8 (MAPT) S214 PhosphoSitePlus 21204788
P10636-8 (MAPT) T231 PhosphoSitePlus 21204788
P10636 (MAPT) S255 neXtProt 23583109, 21204788
P10636-8 (MAPT) S262 PhosphoSitePlus 21204788
P10636 (MAPT) S355 neXtProt 23583109, 21204788
P10636-8 (MAPT) S356 PhosphoSitePlus 21204788
P10636-8 (MAPT) S396 neXtProt   PhosphoSitePlus 23583109, 21204788
P10636-8 (MAPT) S422 PhosphoSitePlus 21204788
P11908 (PRPS2) S180 Signor 29074724
P13569 (CFTR) S737 PhosphoSitePlus   Signor 19095655, 19419994
P13569 (CFTR) S768 neXtProt   PhosphoSitePlus   Signor 19095655, 19419994
P13569 (CFTR) S813 PhosphoSitePlus 21455600
P14859 (POU2F1) S335 PhosphoSitePlus 25937278
P14859 (POU2F1) S385 Signor 9368058, 1684878
P15056 (BRAF) S729 PhosphoSitePlus 24095280
P15531 (NME1) S122 RLIMS-P+ 17135357, 16847342
P15531 (NME1) S144 RLIMS-P+ 16847342
P17600 (SYN1) S9 Signor 10880969
P19429 (TNNI3) S23 neXtProt   PhosphoSitePlus 22456184
P19429 (TNNI3) S24 neXtProt   PhosphoSitePlus 22456184
P19429 (TNNI3) S150 neXtProt   PhosphoSitePlus 22493448, 22456184
P29474 (NOS3) T495 Signor 24379783
P29474 (NOS3) S633 neXtProt   PhosphoSitePlus 20479254, 19131647
P29474 (NOS3) S1177 PhosphoSitePlus   Signor 20479254, 18303014, 17276402, ...12791703
P36956-3 (SREBF1) S372 PhosphoSitePlus 21459323
P41235 (HNF4A) S303 Signor 12740371
P41235 (HNF4A) S313 PhosphoSitePlus 12740371
P42345 (MTOR) T2446 HPRD 14970221
P43405 (SYK) S178 PhosphoSitePlus 22848421
P46527 (CDKN1B) T198 PhosphoSitePlus 17237771
P46937 (YAP1) S61 PhosphoSitePlus 25751139
P46937 (YAP1) S94 PhosphoSitePlus 25751140
P49116 (NR2C2) S351 Signor 21478464
P49674 (CSNK1E) S389 PhosphoSitePlus 17525164
P50552 (VASP) T278 PhosphoSitePlus 17082196
P52292 (KPNA2) S105 PhosphoSitePlus   Signor 15342649
P54840 (GYS2) S8 neXtProt 22233421
P55011 (SLC12A2) S77 RLIMS-P+ 24702155
P60891 (PRPS1) S180 Signor 29074724
P63244 (RACK1) T50 PhosphoSitePlus 26549445
Q04759 (PRKCQ) T538 neXtProt 22330070
Q05469 (LIPE) S855 PhosphoSitePlus   Signor 9636039, 2537200, 16188906
Q06210 (GFPT1) S242 Signor 19170765
Q06210-2 (GFPT1) S243 PhosphoSitePlus 19170765
Q06210 (GFPT1) S261 PhosphoSitePlus   Signor 17941647
Q07866 (KLC1) S521 PhosphoSitePlus 21099273, 20074060
Q09472 (EP300) S89 PhosphoSitePlus   Signor 11518699, 21940946
Q12778 (FOXO1) T649 PhosphoSitePlus 25065674
Q13002-2 (GRIK2) S715 HPRD 8163463, 8094892
Q13085-2 (ACACA) S22 HPRD 2900138, 18212344, 18767875, ...19651622, 18669648, 18707149, 20166139, 11052978, 20068231
Q13085 (ACACA) S80 HPRD   PhosphoSitePlus 2900138, 18303014, 18212344, ...18767875, 18707149, 19651622, 18669648, 17276402, 26456332, 20166139, 7907095, 19176702, 20068231
Q13085-4 (ACACA) S117 HPRD 2900138, 18212344, 18767875, ...19651622, 18669648, 18707149, 20166139, 11052978, 20068231
Q13085-1 (ACACA) S1201 HPRD 2900138, 7907095
Q13085-4 (ACACA) S1238 HPRD 2900138, 7907095
Q13131 (PRKAA1) T183 PhosphoSitePlus 19376078
Q13131 (PRKAA1) S360 PhosphoSitePlus 19376078
Q13131 (PRKAA1) T388 PhosphoSitePlus 19376078
Q13131 (PRKAA1) S486 PhosphoSitePlus 19376078
Q13131 (PRKAA1) S494 PhosphoSitePlus 19376078
Q13131 (PRKAA1) S496 PhosphoSitePlus 19376078
Q13362 (PPP2R5C) S298 PhosphoSitePlus 19366811
Q13362 (PPP2R5C) S336 PhosphoSitePlus 19366811
Q13363 (CTBP1) S158 PhosphoSitePlus   Signor 23291169
Q13621 (SLC12A1) S122 neXtProt 17341212
Q13621 (SLC12A1) S130 PhosphoSitePlus 19176702
Q15036 (SNX17) S437 PhosphoSitePlus 26456332
Q16526 (CRY1) S71 Signor 21892142
Q16875 (PFKFB3) S461 neXtProt   PhosphoSitePlus   Signor 12065600
Q53ET0 (CRTC2) S170 Signor 21892142
Q6N021 (TET2) S99 Signor 30022161
Q7Z3C6 (ATG9A) S761 PhosphoSitePlus 25266655
Q7Z628 (NET1) S100 PhosphoSitePlus 26456332
Q86TI0 (TBC1D1) S237 neXtProt   PhosphoSitePlus   Signor 17995453, 20837646
Q86TI0 (TBC1D1) T596 PhosphoSitePlus 17995453
Q8IXJ6 (SIRT2) T101 PhosphoSitePlus 24446434
Q8N122 (RPTOR) S722 PhosphoSitePlus 26397365, 18439900
Q8N122 (RPTOR) S792 PhosphoSitePlus 26397365, 18439900
Q8WUI4 (HDAC7) S155 Signor 21892142
Q8WUI4 (HDAC7) S358 Signor 21892142
Q92538 (GBF1) T1337 PhosphoSitePlus   Signor 18063581, 23418352
Q9BU19 (ZNF692) S470 PhosphoSitePlus   Signor 17097062
Q9BZL4 (PPP1R12C) S452 PhosphoSitePlus 26456332
Q9GZY8 (MFF) S155 Signor 26816379
Q9GZY8 (MFF) S172 Signor 26816379
Q9H0B6 (KLC2) S539 neXtProt 21436401
Q9H0B6 (KLC2) S545 PhosphoSitePlus 21725060
Q9H0B6 (KLC2) S581 neXtProt 21436401
Q9H0B6 (KLC2) S582 PhosphoSitePlus   Signor 21725060
Q9NYV6 (RRN3) S635 PhosphoSitePlus   Signor 19815529
Q9UBK2 (PPARGC1A) T178 Signor 17609368
Q9UQK1 (PPP1R3C) S33 PhosphoSitePlus 19171932
Q9UQK1 (PPP1R3C) S293 PhosphoSitePlus 19171932
Q9UQL6 (HDAC5) S259 neXtProt   PhosphoSitePlus   Signor 18184930, 21892142
Q9UQL6 (HDAC5) S498 neXtProt   PhosphoSitePlus   Signor 18184930, 21892142
Q9Y478 (PRKAB1) S24 PhosphoSitePlus 19376078
Q9Y478 (PRKAB1) T80 PhosphoSitePlus 19376078
Q9Y478 (PRKAB1) S108 PhosphoSitePlus   Signor 19376078, 17728241
Q9Y478 (PRKAB1) T148 PhosphoSitePlus 25792737
Q9Y478 (PRKAB1) T158 PhosphoSitePlus 19376078
Q9Y478 (PRKAB1) S174 PhosphoSitePlus 19376078
Q9Y478 (PRKAB1) S177 PhosphoSitePlus 19376078


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048901 (hPRKAA1/Phos:1) pT183 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15831 (STK11) S428 Q13131 (PRKAA1) unknown eFIP 16407220
Phosphorylation Q96AD5 (PNPLA2) S404 Q13131 (PRKAA1) increased_association eFIP 22713505