iPTMnet Report for Q13127 (REST)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13127 / REST_HUMAN
Protein Name RE1-silencing transcription factor
Gene Name Name: REST
Synonyms:NRSF,XBR;
Organism Homo sapiens (Human)

PRO ID PR:Q13127
DAG View
PRO Name RE1-silencing transcription factor (human)
Definition An RE1-silencing transcription factor that is encoded in the genome of human.
Short Label hREST
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13127 (REST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S85 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K545 Acetylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
K552 Acetylation PhosphoSitePlus
K569 Acetylation PhosphoSitePlus
K570 Acetylation PhosphoSitePlus
K576 Acetylation PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
S861 Phosphorylation PhosphoSitePlus
S864 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 20068231
C945 Methylation IEDB 31844290
T960 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
K1048 Ubiquitination PhosphoSitePlus
K1054 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1077 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K545 N545 Biomuta DOID:1319 / brain cancer [ icgc ]
K546 N546 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K569 R569 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K582 I582 Biomuta DOID:363 / uterine cancer [ cosmic ]
S750 T750 Biomuta DOID:4159 / skin cancer [ cosmic ]
S864 P864 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S986 F986 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1027 G1027 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]