iPTMnet Report for Q13115 (DUSP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13115 / DUS4_HUMAN
Protein Name Dual specificity protein phosphatase 4
Gene Name Name: DUSP4
Synonyms:MKP2,VH2;
Organism Homo sapiens (Human)

PRO ID PR:Q13115
DAG View
PRO Name dual specificity protein phosphatase 4 (human)
Definition A dual specificity protein phosphatase 4 that is encoded in the genome of human.
Short Label hDUSP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13115 (DUSP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
V2 Acetylation UniProt 25489052
C12 Methylation IEDB 31844290
K16 Ubiquitination PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21084841
S391 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21084841
Site PTM Type PTM Enzyme Score Source PMID
S33 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C12 Y12 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y60 C60 Biomuta DOID:1324 / lung cancer [ cosmic ]
S112 N112 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S159 C159 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S345 I345 Biomuta DOID:1324 / lung cancer [ cosmic ]
S386 N386 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]