iPTMnet Report for Q13098 (GPS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13098 / CSN1_HUMAN
Protein Name COP9 signalosome complex subunit 1
Gene Name Name: GPS1
Synonyms:COPS1,CSN1;
Organism Homo sapiens (Human)

PRO ID PR:Q13098
DAG View
PRO Name COP9 signalosome complex subunit 1 (human)
Definition A COP9 signalosome complex subunit 1 that is encoded in the genome of human.
Short Label hGPS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13098 (GPS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C67 Methylation IEDB 31844290
Y91 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
C175 Methylation IEDB 31844290
K183 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
C269 Methylation IEDB 31844290
C278 Methylation IEDB 31844290
K332 Acetylation PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
S468 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340, ...18850735
S474 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18850735, ...18077418, 18669648, 20068231
S474 Phosphorylation Q13535 (ATR) PhosphoSitePlus 18077418
T479 Phosphorylation PhosphoSitePlus   UniProt 17525332, 23186163, 16964243, ...21406692, 18669648, 19690332, 20068231, 18850735
S483 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 18850735
S485 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S468 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
S474 Phosphorylation HPRD 19413330, 17525332, 19664994, ...19664995, 19651622, 18669648, 20068231
T479 Phosphorylation HPRD 19413330, 17525332, 16964243, ...19664994, 19664995, 19651622, 18669648, 20068231
S483 Phosphorylation HPRD 17525332, 18669648
S488 Phosphorylation HPRD 17287340
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S504 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
S510 Phosphorylation HPRD 19413330, 17525332, 19664994, ...19664995, 19651622, 18669648, 20068231
T515 Phosphorylation HPRD 19413330, 17525332, 16964243, ...19664994, 19664995, 19651622, 18669648, 20068231
S519 Phosphorylation HPRD 17525332, 18669648
S524 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K332 I332 Biomuta DOID:3571 / liver cancer [ cosmic ]
K332 T332 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K422 R422 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S468 T468 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S483 I483 Biomuta DOID:3571 / liver cancer [ cosmic ]
S504 T504 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S519 I519 Biomuta DOID:3571 / liver cancer [ cosmic ]