iPTMnet Report for Q13064 (MKRN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13064 / MKRN3_HUMAN
Protein Name Probable E3 ubiquitin-protein ligase makorin-3
Gene Name Name: MKRN3
Synonyms:D15S9,RNF63,ZNF127;
Organism Homo sapiens (Human)

PRO ID PR:Q13064
DAG View
PRO Name probable E3 ubiquitin-protein ligase makorin-3 (human)
Definition A makorin-3 that is encoded in the genome of human.
Short Label hMKRN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13064 (MKRN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R69 Methylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
C400 Methylation IEDB 31844290
K476 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R69 K69 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R73 K73 Biomuta DOID:4159 / skin cancer [ cosmic ]
K384 N384 Biomuta DOID:3571 / liver cancer [ cosmic ]
K386 I386 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K392 N392 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
C400 S400 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
C400 * Biomuta DOID:1324 / lung cancer [ cosmic ]