Protein Information

Cytoscape View

UniProt AC / UniProt ID Q13057 / COASY_HUMAN
Protein Name Bifunctional coenzyme A synthase
Gene Name Name: COASY
Organism Homo sapiens (Human)

PRO ID PR:Q13057
DAG View
PRO Name bifunctional coenzyme A synthase (human)
Definition A bifunctional coenzyme A synthase that is encoded in the genome of human.
Short Label hCOASY
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q13057 (COASY) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S178 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 15302935, 24275569, ...19690332, 20068231
S183 Phosphorylation PhosphoSitePlus   UniProt 20068231
T199 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S149 Phosphorylation HPRD 20068231
Y153 Phosphorylation HPRD 20068231
S172 Phosphorylation HPRD 20068231
T173 Phosphorylation HPRD 20068231
S178 Phosphorylation HPRD 15302935, 18088087, 20068231
S183 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S178 Phosphorylation HPRD 20068231
Y182 Phosphorylation HPRD 20068231
S201 Phosphorylation HPRD 20068231
T202 Phosphorylation HPRD 20068231
S207 Phosphorylation HPRD 18088087, 20068231
S212 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 F24 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S28 L28 Biomuta DOID:8618 / oral cavity cancer [ icgc ] DOID:11054 / urinary bladder cancer [ tcga ]
S28 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S149 L149 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S183 F183 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K417 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]