Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13045 / FLII_HUMAN
Protein Name Protein flightless-1 homolog
Gene Name Name: FLII
Synonyms:FLIL;
Organism Homo sapiens (Human)

PRO ID PR:Q13045
DAG View
PRO Name protein flightless-1 homolog (human)
Definition A protein flightless-1 that is encoded in the genome of human.
Short Label hFLII
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13045 (FLII) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 12665801, 22223895
T4 Phosphorylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus   UniProt 19608861
K21 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus
S406 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
T409 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S418 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
S436 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17081983, 24275569, ...20068231, 19293151
S436 Phosphorylation Q96BR1 (SGK3) neXtProt   PhosphoSitePlus   Signor 19293151
K447 Ubiquitination PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
Y523 Phosphorylation PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
Y657 Phosphorylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
Y737 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
T772 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
T818 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 19293151
T818 Phosphorylation Q96BR1 (SGK3) neXtProt   PhosphoSitePlus   Signor 19293151
S822 Phosphorylation PhosphoSitePlus
K832 Methylation PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
S856 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 15302935, 18669648, 24275569, 19690332, 20068231, 17081983
S860 Phosphorylation PhosphoSitePlus   UniProt 23186163
K862 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
Y946 Phosphorylation PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K962 Ubiquitination PhosphoSitePlus
T968 Phosphorylation PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
K1035 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
Y1102 Phosphorylation PhosphoSitePlus
K1115 Ubiquitination PhosphoSitePlus
K1162 Ubiquitination PhosphoSitePlus
K1173 Ubiquitination PhosphoSitePlus
Y1175 Phosphorylation PhosphoSitePlus
Y1227 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S406 Phosphorylation HPRD 18669648, 16964243, 20068231
T409 Phosphorylation HPRD 18669648, 20068231
S436 Phosphorylation HPRD 19651622, 17081983, 20068231
S768 Phosphorylation HPRD 20068231
S856 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20058876, 19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 18767875, 19415658, 20068231
S860 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S352 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K92 R92 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y657 C657 Biomuta DOID:4362 / cervical cancer [ tcga ]
K752 N752 Biomuta DOID:363 / uterine cancer [ tcga ]
K756 E756 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K756 N756 Biomuta DOID:1324 / lung cancer [ tcga ]
T772 A772 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K802 E802 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S860 T860 Biomuta DOID:363 / uterine cancer [ tcga ]
S860 F860 Biomuta DOID:1909 / melanoma [ tcga ]
K874 N874 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K951 N951 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K951 R951 Biomuta DOID:363 / uterine cancer [ icgc ]
K1046 R1046 Biomuta DOID:263 / kidney cancer [ tcga ]
K1162 Q1162 Biomuta DOID:3277 / thymus cancer [ tcga ]