Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13043 / STK4_HUMAN
Protein Name Serine/threonine-protein kinase 4
Gene Name Name: STK4
Synonyms:KRS2,MST1;
Organism Homo sapiens (Human)

PRO ID PR:Q13043
DAG View
PRO Name serine/threonine-protein kinase 4 (human)
Definition A serine/threonine-protein kinase 4 that is encoded in the genome of human.
Short Label hSTK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13043 (STK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19369195, 22814378, 22223895
T3 Phosphorylation PhosphoSitePlus   UniProt 19369195
S21 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K59 Methylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S82 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   Signor 20028971
K119 Ubiquitination PhosphoSitePlus
T120 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 19940129
S132 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T177 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus 12223493
K180 Ubiquitination PhosphoSitePlus
T183 Phosphorylation Q13043 (STK4) , P26927 (MST1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 15109305, 12223493, 11805089, ...19940129
T238 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus   UniProt 18691976
K285 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 19369195, ...18669648, 24275569, 19690332, 20068231
S327 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
T340 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   UniProt 18691976, 21851590, 23186163, ...19369195
T353 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus   UniProt 19369195
T380 Phosphorylation PhosphoSitePlus
T387 Phosphorylation Q9Y243 (AKT3) , Q13043 (STK4) , P31749 (AKT1) , P31751 (AKT2) neXtProt   PhosphoSitePlus   Signor   UniProt 17726016, 12223493, 23186163, ...23431053
S394 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
K413 Ubiquitination PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
K420 Ubiquitination PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
Y433 Phosphorylation P00519 (ABL1) phospho.ELM   PhosphoSitePlus 21715626, 17192257
K437 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T175 Phosphorylation HPRD 18691976
T177 Phosphorylation Q13043 (STK4) HPRD 12223493, 18452278
T183 Phosphorylation Q13043 (STK4) HPRD   PRO 11278283, 9545236, 12223493
T187 Phosphorylation Q13043 (STK4) HPRD 12223493
T238 Phosphorylation HPRD 20068231
T243 Phosphorylation HPRD 20068231
S265 Phosphorylation HPRD 18691976
S320 Phosphorylation HPRD 18691976, 18452278, 18669648, ...20166139, 15345747, 19415658, 20068231
S327 Phosphorylation Q13043 (STK4) HPRD 18691976, 12223493
T329 Phosphorylation HPRD 18452278
T340 Phosphorylation HPRD 18691976, 18212344
S410 Phosphorylation HPRD 18691976
Y433 Phosphorylation HPRD 18707149
S438 Phosphorylation HPRD 18691976


Q13043 (STK4) as PTM Enzyme



Substrate Site Score Source PMID
O43524 (FOXO3) S209 neXtProt   PhosphoSitePlus   Signor 22898666, 18394876, 16751106
O43524 (FOXO3) S215 neXtProt   PhosphoSitePlus 16751106
O43524 (FOXO3) S231 PhosphoSitePlus 16751106
O43524 (FOXO3) S232 PhosphoSitePlus 16751106
O43524 (FOXO3) S243 neXtProt   PhosphoSitePlus 16751106
O95835 (LATS1) S909 Signor 15688006
O95835 (LATS1) T1079 Signor 15688006
P00519 (ABL1) T735 neXtProt   PhosphoSitePlus   Signor 18794806
P19429 (TNNI3) T31 neXtProt   PhosphoSitePlus   Signor 18986304
P19429 (TNNI3) T51 neXtProt   PhosphoSitePlus   Signor 18986304
P19429 (TNNI3) T129 neXtProt   PhosphoSitePlus   Signor 18986304
P19429 (TNNI3) T143 neXtProt   PhosphoSitePlus   Signor 18986304
P33778 (HIST1H2BB) S15 Signor 21212262
Q06830 (PRDX1) T18 PhosphoSitePlus 23386615
Q06830 (PRDX1) T90 PhosphoSitePlus 23386615
Q06830 (PRDX1) T183 PhosphoSitePlus 23386615
Q12778 (FOXO1) S212 neXtProt   Signor 19221179, 22898666, 18394876, ...18786403
Q13043-1 (STK4) T177 HPRD   neXtProt 12223493, 18452278
Q13043 (STK4) T183 HPRD   neXtProt   PhosphoSitePlus   UniProt 15109305, 11805089, 12223493, ...19940129
Q13043-1 (STK4) T187 HPRD 12223493
Q13043-1 (STK4) S327 HPRD 18691976, 12223493
Q13043 (STK4) T387 neXtProt 12223493
Q14457 (BECN1) T108 PhosphoSitePlus 24141421
Q15208 (STK38) T444 neXtProt   PhosphoSitePlus 19062280, 19836237
Q7L9L4 (MOB1B) T12 PhosphoSitePlus   Signor 21808241, 18328708, 23431053
Q7L9L4 (MOB1B) T35 PhosphoSitePlus   Signor 21808241, 18328708, 23431053
Q96GD4 (AURKB) T232 PhosphoSitePlus 20171103
Q9H492 (MAP1LC3A) T50 RLIMS-P+ 25544559
Q9H8S9 (MOB1A) T12 neXtProt   Signor 21808241, 18328708, 23431053
Q9H8S9 (MOB1A) T35 neXtProt   Signor 21808241, 18328708, 23431053
Q9NRM7 (LATS2) S872 Signor 21808241, 23431053
Q9NRM7 (LATS2) T1041 Signor 21808241, 23431053
Q9NS23-2 (RASSF1) T202 neXtProt 19062280
Q9NS23-2 (RASSF1) S203 neXtProt 19062280


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049369 (hSTK4/Phos:1) pT183 PRO
PR:000035909 (hSTK4/Clv:37kDa) pT183 PRO 11278283, 9545236


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q13043 (hSTK4) Interaction PR:Q96GD4 (hAURKB) PRO 20171103
PR:Q13043 (hSTK4) Interaction PR:Q96GD4 (hAURKB) PRO 20171103
PR:Q13043 (hSTK4) Interaction PRO 20171103
PR:Q13043 (hSTK4) Interaction PRO 20171103
PR:Q13043 (hSTK4) Interaction PR:Q96GD4 (hAURKB) PRO 20171103
PR:Q13043 (hSTK4) Interaction PRO 20171103
PR:Q8WWW0-2 (hRASSF5/iso:2) Interaction PR:Q13043 (hSTK4) PRO 16892067
PR:Q8WWW0-2 (hRASSF5/iso:2) Interaction PR:Q13043 (hSTK4) PRO 16892067
PR:Q8WWW0-2 (hRASSF5/iso:2) Interaction PR:Q13043 (hSTK4) PRO 16892067
PR:Q96GD4 (hAURKB) Interaction PR:Q13043 (hSTK4) PRO 20171103
PR:Q96GD4 (hAURKB) Interaction PR:Q13043 (hSTK4) PRO 20171103
PR:Q96GD4 (hAURKB) Interaction PR:Q13043 (hSTK4) PRO 20171103


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 N46 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T120 M120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T177 A177 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T360 M360 Biomuta DOID:10534 / stomach cancer [ tcga ]
K420 E420 Biomuta DOID:1909 / melanoma [ cosmic ]
K437 N437 Biomuta DOID:363 / uterine cancer [ tcga ]