iPTMnet Report for Q13017 (ARHGAP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13017 / RHG05_HUMAN
Protein Name Rho GTPase-activating protein 5
Gene Name Name: ARHGAP5
Synonyms:RHOGAP5;
Organism Homo sapiens (Human)

PRO ID PR:Q13017
DAG View
PRO Name Rho GTPase-activating protein 5 (human)
Definition A Rho GTPase-activating protein 5 that is encoded in the genome of human.
Short Label hARHGAP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13017 (ARHGAP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation phospho.ELM   PhosphoSitePlus 12705864
Y306 Phosphorylation P06213 (INSR) PhosphoSitePlus 12705864
K314 Acetylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus   UniProt 23186163
T591 Phosphorylation PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
S862 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus   UniProt 20068231
S968 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S981 Phosphorylation PhosphoSitePlus
Y1019 Phosphorylation PhosphoSitePlus
T1024 Phosphorylation PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
Y1091 Phosphorylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
Y1104 Phosphorylation PhosphoSitePlus
S1105 Phosphorylation PhosphoSitePlus
Y1109 Phosphorylation PhosphoSitePlus   Signor 18829532, 10713673
Y1109 Phosphorylation P12931 (SRC) PhosphoSitePlus 10713673
Y1109 Phosphorylation Q13882 (PTK6) PhosphoSitePlus   Signor 18829532
S1115 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1124 Phosphorylation PhosphoSitePlus
T1129 Phosphorylation PhosphoSitePlus
S1138 Phosphorylation PhosphoSitePlus
T1159 Phosphorylation PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569
S1176 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S1184 Phosphorylation PhosphoSitePlus
S1195 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S1202 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...19690332, 20068231
T1206 Phosphorylation PhosphoSitePlus
T1217 Phosphorylation PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1396 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S590 Phosphorylation HPRD 20068231
T680 Phosphorylation HPRD 18452278
S765 Phosphorylation HPRD 18691976, 20068231
S951 Phosphorylation HPRD 20068231
S968 Phosphorylation HPRD 18669648
S1115 Phosphorylation HPRD 18669648
S1124 Phosphorylation HPRD 18669648
T1129 Phosphorylation HPRD 18669648
S1138 Phosphorylation HPRD 18669648
S1173 Phosphorylation HPRD 19651622, 18669648, 20068231
S1176 Phosphorylation HPRD 19651622, 18669648, 20068231
S1195 Phosphorylation HPRD 18669648, 18452278
S1202 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19664994, 20068231
T1217 Phosphorylation HPRD 18691976
S1218 Phosphorylation HPRD 19413330, 18691976, 18767875, ...20058876, 18452278, 17322306, 18669648, 20068231
S1299 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S590 Phosphorylation HPRD 20068231
T680 Phosphorylation HPRD 18452278
S765 Phosphorylation HPRD 18691976, 20068231
S951 Phosphorylation HPRD 20068231
S968 Phosphorylation HPRD 18669648
S1115 Phosphorylation HPRD 18669648
S1124 Phosphorylation HPRD 18669648
T1129 Phosphorylation HPRD 18669648
S1138 Phosphorylation HPRD 18669648
S1173 Phosphorylation HPRD 19651622, 18669648, 20068231
S1176 Phosphorylation HPRD 19651622, 18669648, 20068231
S1195 Phosphorylation HPRD 18669648, 18452278
S1202 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19664994, 20068231
T1217 Phosphorylation HPRD 18691976
S1218 Phosphorylation HPRD 19413330, 18691976, 18767875, ...20058876, 18452278, 17322306, 18669648, 20068231
S1298 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 N16 Biomuta DOID:1319 / brain cancer [ icgc ]
S862 L862 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S1105 F1105 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1124 L1124 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1124 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]