iPTMnet Report for Q13009 (TIAM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q13009 / TIAM1_HUMAN
Protein Name Rho guanine nucleotide exchange factor TIAM1
Gene Name Name: TIAM1
Organism Homo sapiens (Human)

PRO ID PR:Q13009
DAG View
PRO Name Rho guanine nucleotide exchange factor TIAM1 (human)
Definition A Rho guanine nucleotide exchange factor TIAM1 that is encoded in the genome of human.
Short Label hTIAM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q13009 (TIAM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
T26 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus   RLIMS-P 26941335
S33 Phosphorylation PhosphoSitePlus   RLIMS-P 26941335
S43 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus   RLIMS-P 19899799
Y135 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus   RLIMS-P 19899799
S224 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 19369195, 21406692, 25746002, ...19899799, 19690332
S231 Phosphorylation P31749 (AKT1) PhosphoSitePlus 25746002
T288 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus   RLIMS-P 19285946
S456 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
K596 Acetylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
Y820 Phosphorylation PhosphoSitePlus
Y829 Phosphorylation neXtProt   PRO 16801538
Y829 Phosphorylation Q16620 (NTRK2) neXtProt 16801538
K887 Methylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
S998 Phosphorylation PhosphoSitePlus
Y1142 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
S1317 Phosphorylation PhosphoSitePlus
S1321 Phosphorylation PhosphoSitePlus
Y1323 Phosphorylation PhosphoSitePlus
T1337 Phosphorylation PhosphoSitePlus
K1397 Methylation PhosphoSitePlus
K1404 Ubiquitination UniProt 25684205
S1407 Phosphorylation PhosphoSitePlus
Y1414 Phosphorylation PhosphoSitePlus
K1420 Acetylation PhosphoSitePlus
K1420 Ubiquitination UniProt 25684205
S1437 Phosphorylation PhosphoSitePlus
S1442 Phosphorylation PhosphoSitePlus
T1456 Phosphorylation PhosphoSitePlus
S1463 Phosphorylation PhosphoSitePlus
S1466 Phosphorylation PhosphoSitePlus   RLIMS-P 26078008
T1502 Phosphorylation PhosphoSitePlus
S1506 Phosphorylation PhosphoSitePlus
S1519 Phosphorylation PhosphoSitePlus
S1534 Phosphorylation PhosphoSitePlus
S1560 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S231 Phosphorylation HPRD 19664994, 20058876
S356 Phosphorylation HPRD 19413330
S358 Phosphorylation HPRD 19413330, 19664994
S1466 Phosphorylation HPRD 19664994
S1506 Phosphorylation HPRD 19664994
T1542 Phosphorylation HPRD 17322306


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049451 (hTIAM1/InitMet-/Phos:1) pY829 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 G20 Biomuta DOID:1612 / breast cancer [ cosmic ]
S43 C43 Biomuta DOID:4159 / skin cancer [ cosmic ]
S52 F52 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y135 S135 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y135 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S170 F170 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S172 F172 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S231 F231 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S298 F298 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S311 N311 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T319 R319 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S334 R334 Biomuta DOID:1612 / breast cancer [ cosmic ]
S356 N356 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S726 Y726 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S726 F726 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T992 A992 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1317 F1317 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1321 F1321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1337 M1337 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1337 K1337 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S1442 F1442 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1463 F1463 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1502 K1502 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1534 G1534 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1542 I1542 Biomuta DOID:4159 / skin cancer [ cosmic ]