iPTMnet Report for Q12972 (PPP1R8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12972 / PP1R8_HUMAN
Protein Name Nuclear inhibitor of protein phosphatase 1
Gene Name Name: PPP1R8
Synonyms:ARD1,NIPP1;
Organism Homo sapiens (Human)

PRO ID PR:Q12972
DAG View
PRO Name nuclear inhibitor of protein phosphatase 1 (human)
Definition A nuclear inhibitor of protein phosphatase 1 that is encoded in the genome of human.
Short Label hPPP1R8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12972 (PPP1R8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K138 Sumoylation PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
T161 Phosphorylation phospho.ELM 9407077
K175 Ubiquitination PhosphoSitePlus
S178 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 9407077
K193 Sumoylation PhosphoSitePlus
S199 Phosphorylation phospho.ELM   PhosphoSitePlus 9407077
T202 Phosphorylation PhosphoSitePlus
S204 Phosphorylation phospho.ELM   PhosphoSitePlus 9407077
K236 Methylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y264 Phosphorylation phospho.ELM   UniProt 11104670
Y264 Phosphorylation P07948 (LYN) phospho.ELM 11104670
T284 O-Glycosylation GlyGen 29485866, 32119511, 34019948, ...28510447, 29351928
Y335 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11104670
Y335 Phosphorylation P07948 (LYN) phospho.ELM   PhosphoSitePlus 11104670
T346 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T161 Phosphorylation HPRD 9407077
T161 Phosphorylation P19784 (CSNK2A2) HPRD 9407077
T161 Phosphorylation P68400 (CSNK2A1) HPRD 9407077
S178 Phosphorylation HPRD 18669648, 9407077, 20068231
S178 Phosphorylation P17612 (PRKACA) HPRD 18669648, 9407077, 20068231
S199 Phosphorylation HPRD 9407077
S199 Phosphorylation P17612 (PRKACA) HPRD 9407077
S204 Phosphorylation HPRD 9407077
S204 Phosphorylation P19784 (CSNK2A2) HPRD 9407077
S204 Phosphorylation P68400 (CSNK2A1) HPRD 9407077
S243 Phosphorylation HPRD 20068231
S249 Phosphorylation HPRD 20068231
Y264 Phosphorylation HPRD 11104670
Y264 Phosphorylation P07948 (LYN) HPRD 11104670
Y335 Phosphorylation HPRD 11104670
Y335 Phosphorylation P07948 (LYN) HPRD 11104670
Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation HPRD 9407077
T19 Phosphorylation P19784 (CSNK2A2) HPRD 9407077
T19 Phosphorylation P68400 (CSNK2A1) HPRD 9407077
S36 Phosphorylation HPRD 18669648, 9407077, 20068231
S36 Phosphorylation P17612 (PRKACA) HPRD 18669648, 9407077, 20068231
S57 Phosphorylation HPRD 9407077
S57 Phosphorylation P17612 (PRKACA) HPRD 9407077
S62 Phosphorylation HPRD 9407077
S62 Phosphorylation P19784 (CSNK2A2) HPRD 9407077
S62 Phosphorylation P68400 (CSNK2A1) HPRD 9407077
S101 Phosphorylation HPRD 20068231
S107 Phosphorylation HPRD 20068231
Y122 Phosphorylation HPRD 11104670
Y122 Phosphorylation P07948 (LYN) HPRD 11104670
Y193 Phosphorylation HPRD 11104670
Y193 Phosphorylation P07948 (LYN) HPRD 11104670
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 20068231
S25 Phosphorylation HPRD 20068231
Y40 Phosphorylation HPRD 11104670
Y40 Phosphorylation P07948 (LYN) HPRD 11104670
Y111 Phosphorylation HPRD 11104670
Y111 Phosphorylation P07948 (LYN) HPRD 11104670


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T19 P19 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S36 C36 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T161 P161 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S178 C178 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T202 K202 Biomuta DOID:2531 / hematologic cancer [ cosmic ]