Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12968 / NFAC3_HUMAN
Protein Name Nuclear factor of activated T-cells, cytoplasmic 3
Gene Name Name: NFATC3
Synonyms:NFAT4;
Organism Homo sapiens (Human)

PRO ID PR:Q12968
DAG View
PRO Name nuclear factor of activated T-cells, cytoplasmic 3 (human)
Definition A nuclear factor of activated T-cells, cytoplasmic 3 that is encoded in the genome of human.
Short Label hNFATC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12968 (NFATC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
S163 Phosphorylation P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9374467
S165 Phosphorylation P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 27863227, 9374467
S168 Phosphorylation PRO
S169 Phosphorylation PRO
S171 Phosphorylation PRO
S172 Phosphorylation PRO   PhosphoSitePlus
S174 Phosphorylation PRO
S177 Phosphorylation PhosphoSitePlus   RLIMS-P 11781102
S180 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
T204 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   Signor 9630228
S207 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   Signor 9630228
T210 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   Signor 9630228
S211 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   Signor 9630228
S215 Phosphorylation P48729 (CSNK1A1) phospho.ELM   PhosphoSitePlus   Signor 9630228
S236 Phosphorylation PRO   PhosphoSitePlus
S240 Phosphorylation PRO
S244 Phosphorylation PRO
S247 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PRO   PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PRO   PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PRO   PhosphoSitePlus
S300 Phosphorylation PRO   PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PRO   PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus   UniProt 23186163
K384 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
Y884 Phosphorylation PhosphoSitePlus
S1045 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1066 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S163 Phosphorylation P45984 (MAPK9) HPRD 9374467
S165 Phosphorylation P45984 (MAPK9) HPRD 9374467
T204 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S207 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
T210 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S211 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S215 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S366 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S163 Phosphorylation P45984 (MAPK9) HPRD 9374467
S165 Phosphorylation P45984 (MAPK9) HPRD 9374467
T204 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S207 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
T210 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S211 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S215 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S366 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S163 Phosphorylation P45984 (MAPK9) HPRD 9374467
S165 Phosphorylation P45984 (MAPK9) HPRD 9374467
T204 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S207 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
T210 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S211 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S215 Phosphorylation P48729 (CSNK1A1) HPRD 9630228
S366 Phosphorylation HPRD 19664994


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048592 (hNFATC3/InitMet-/Phos:1) pS168,pS169,pS171,pS172,pS174,pS236,pS240,pS244,pS265,pS288,pS296,pS300,pS344 PRO
PR:000048593 (hNFATC3/InitMet-/Phos:2) pS265 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S117 C117 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S240 F240 Biomuta DOID:1324 / lung cancer [ cosmic ]
S269 Y269 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S288 L288 Biomuta DOID:1324 / lung cancer [ tcga ]
S296 L296 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S364 I364 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K384 N384 Biomuta DOID:1909 / melanoma [ tcga ]
K405 R405 Biomuta DOID:1324 / lung cancer [ cosmic ]
S416 L416 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K467 N467 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic, tcga ] DOID:3070 / malignant glioma [ tcga ]
K467 E467 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K552 N552 Biomuta DOID:1324 / lung cancer [ cosmic ]
S731 C731 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
Y884 C884 Biomuta DOID:0070003 / blastoma [ cosmic ]
S1066 P1066 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]