iPTMnet Report for Q12959 (DLG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12959 / DLG1_HUMAN
Protein Name Disks large homolog 1
Gene Name Name: DLG1
Organism Homo sapiens (Human)

PRO ID PR:Q12959
DAG View
PRO Name disks large homolog 1 (human)
Definition A disks large homolog 1 that is encoded in the genome of human.
Short Label hDLG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12959 (DLG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y18 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T115 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S122 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16637659
S122 Phosphorylation P53778 (MAPK12) neXtProt 16637659
T126 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus   UniProt 24275569
K140 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S158 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 16637659, 15729360, 20643107, ...19066288, 20068231
S158 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor 19066288
S158 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus   Signor 19066288
S158 Phosphorylation P53778 (MAPK12) neXtProt   PhosphoSitePlus 16637659, 15729360
S158 Phosphorylation Q13164 (MAPK7) PhosphoSitePlus 20643107
T209 Phosphorylation PhosphoSitePlus 15729360
T209 Phosphorylation P53778 (MAPK12) PhosphoSitePlus 15729360
Y222 Phosphorylation RLIMS-P 25098293
S232 Phosphorylation neXtProt   phospho.ELM 12933808
S232 Phosphorylation Q9UQM7 (CAMK2A) neXtProt 12933808
K291 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
Y399 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
S443 Phosphorylation neXtProt   PhosphoSitePlus   Signor 19066288, 16637659, 15729360
S443 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor 19066288
S443 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus   Signor 19066288
S443 Phosphorylation P53778 (MAPK12) neXtProt   PhosphoSitePlus 16637659, 15729360
Y447 Phosphorylation neXtProt   PhosphoSitePlus 16637659
Y447 Phosphorylation P53778 (MAPK12) neXtProt 16637659
S448 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
N566 N-Glycosylation GlyGen 29741879
S567 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S568 Phosphorylation PhosphoSitePlus   UniProt 20068231
S570 Phosphorylation PhosphoSitePlus
S571 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S573 Phosphorylation PhosphoSitePlus   UniProt 24275569
S575 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
T578 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus   UniProt 23186163
S583 Phosphorylation PhosphoSitePlus
Y585 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S619 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
T630 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
K644 Acetylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus 22027822
T657 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 22027822
K659 Ubiquitination PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S676 Phosphorylation UniProt 24275569
K677 Acetylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
S684 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
S687 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 17081983, ...20068231
Q709 Phosphorylation UniProt 24275569
K724 Ubiquitination PhosphoSitePlus
Y753 Phosphorylation PhosphoSitePlus
Y760 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T764 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
Y789 Phosphorylation PhosphoSitePlus
T791 Phosphorylation PhosphoSitePlus
Y824 Phosphorylation PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
Y895 Phosphorylation PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 20068231
S102 Phosphorylation HPRD 18452278
Y108 Phosphorylation HPRD 17081983
Y110 Phosphorylation HPRD 18669648
T115 Phosphorylation HPRD 18669648, 18452278
S122 Phosphorylation HPRD 18669648, 20068231
S143 Phosphorylation HPRD 17081983
S155 Phosphorylation HPRD 20068231
S158 Phosphorylation HPRD 17081983, 20068231
Y409 Phosphorylation HPRD 19901323
S567 Phosphorylation HPRD 18669648, 20068231
S568 Phosphorylation HPRD 17081983, 20068231
S570 Phosphorylation HPRD 17081983
S571 Phosphorylation HPRD 18669648, 17081983, 20068231
S573 Phosphorylation HPRD 20068231
S575 Phosphorylation HPRD 20166139, 18669648, 20068231
S684 Phosphorylation HPRD 18669648
S687 Phosphorylation HPRD 19651622, 18669648, 20068231
Y760 Phosphorylation HPRD 18083107, 17389395
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 20068231
S102 Phosphorylation HPRD 18452278
Y108 Phosphorylation HPRD 17081983
Y110 Phosphorylation HPRD 18669648
T115 Phosphorylation HPRD 18669648, 18452278
S122 Phosphorylation HPRD 18669648, 20068231
S143 Phosphorylation HPRD 17081983
S155 Phosphorylation HPRD 20068231
S158 Phosphorylation HPRD 17081983, 20068231
S232 Phosphorylation HPRD 12933808
S232 Phosphorylation Q9UQM7 (CAMK2A) HPRD 12933808
Y409 Phosphorylation HPRD 19901323
S567 Phosphorylation HPRD 18669648, 20068231
S568 Phosphorylation HPRD 17081983, 20068231
S570 Phosphorylation HPRD 17081983
S571 Phosphorylation HPRD 18669648, 17081983, 20068231
S573 Phosphorylation HPRD 20068231
S575 Phosphorylation HPRD 20166139, 18669648, 20068231
S619 Phosphorylation phospho.ELM 18220336
K644 Acetylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
T705 Phosphorylation HPRD 17081983
S706 Phosphorylation HPRD   PhosphoSitePlus 18669648, 15302935
S709 Phosphorylation HPRD   PhosphoSitePlus 15302935, 18452278, 19651622, ...18669648, 20166139, 20068231
Y715 Phosphorylation PhosphoSitePlus
Y782 Phosphorylation HPRD   PhosphoSitePlus 18083107, 17389395
Site PTM Type PTM Enzyme Score Source PMID
S158 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y3 Phosphorylation PhosphoSitePlus
Y12 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y56 N56 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y110 C110 Biomuta DOID:3571 / liver cancer [ cosmic ]
K140 N140 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S232 L232 Biomuta DOID:3571 / liver cancer [ cosmic ]
S301 Y301 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K370 T370 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S432 G432 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S568 I568 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S571 L571 Biomuta DOID:4159 / skin cancer [ cosmic ]
S583 F583 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y585 C585 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T630 I630 Biomuta DOID:1324 / lung cancer [ cosmic ]
S662 Y662 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S670 L670 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S684 Y684 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S693 I693 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S706 Y706 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y715 C715 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y789 C789 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T853 P853 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ]