iPTMnet Report for Q12933 (TRAF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12933 / TRAF2_HUMAN
Protein Name TNF receptor-associated factor 2
Gene Name Name: TRAF2
Synonyms:TRAP3;
Organism Homo sapiens (Human)

PRO ID PR:Q12933
DAG View
PRO Name TNF receptor-associated factor 2 (human)
Definition A TNF receptor-associated factor 2 that is encoded in the genome of human.
Short Label hTRAF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12933 (TRAF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 19413330, 21406692, 20068231
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
T7 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S11 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21119000, 23186163, 21406692, ...27098354, 24362534, 34277634, 18981220, 23007157, 28726782
S11 Phosphorylation Q14164 (IKBKE) neXtProt 23007157
T22 Phosphorylation PhosphoSitePlus   UniProt 21406692
T26 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus   UniProt 19150425
S55 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 21119000, 19336568, 28726782
S55 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   Signor 19336568
S102 Phosphorylation PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23754945, 19150425
K119 Ubiquitination PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
C182 Methylation IEDB 31844290
K184 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
Y484 Phosphorylation RLIMS-P 14604983
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20058876
T7 Phosphorylation HPRD 19651622, 17081983, 20068231
S11 Phosphorylation HPRD 19651622, 20058876, 17081983, ...20068231
S20 Phosphorylation HPRD 20068231
T22 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049534 (hTRAF2/InitMet-/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S5 N5 Biomuta DOID:1319 / brain cancer [ cosmic ]
K31 T31 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y121 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K176 M176 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S274 I274 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K313 R313 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K320 N320 Biomuta DOID:1324 / lung cancer [ cosmic ]
K477 T477 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K481 N481 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]