Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12931 / TRAP1_HUMAN
Protein Name Heat shock protein 75 kDa, mitochondrial precursor
Gene Name Name: TRAP1
Synonyms:HSP75;
Organism Homo sapiens (Human)

PRO ID PR:Q12931
DAG View
PRO Name heat shock protein 75 kDa, mitochondrial (human)
Definition A heat shock protein 75 kDa, mitochondrial that is encoded in the genome of human.
Short Label hTRAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12931 (TRAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T39 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus   UniProt 23186163
S236 Phosphorylation PhosphoSitePlus
K324 Acetylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
K332 Acetylation PhosphoSitePlus   UniProt 19608861
K332 Ubiquitination PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
Y344 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
R388 Methylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K424 Acetylation PhosphoSitePlus   UniProt 19608861
K431 Acetylation PhosphoSitePlus
K432 Acetylation PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K466 Acetylation PhosphoSitePlus   UniProt 19608861
Y486 Phosphorylation PhosphoSitePlus
T494 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y498 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y499 Phosphorylation PhosphoSitePlus
C501 S-Nitrosylation dbSNO 19483679
R505 Methylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
Y513 Phosphorylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
K518 Acetylation PhosphoSitePlus
R567 Methylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus   UniProt 24275569
C573 S-Nitrosylation dbSNO 26338901
K652 Acetylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T153 Phosphorylation HPRD 20068231
T174 Phosphorylation HPRD 20068231
S282 Phosphorylation HPRD 19651622
S341 Phosphorylation HPRD 20068231
Y366 Phosphorylation HPRD 17924679
T494 Phosphorylation HPRD 18669648
Y498 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T40 I40 Biomuta DOID:3571 / liver cancer [ icgc ]
S121 I121 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K126 N126 Biomuta DOID:1909 / melanoma [ cosmic ]
T333 K333 Biomuta DOID:3571 / liver cancer [ icgc ]
T333 M333 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T333 S333 Biomuta DOID:1324 / lung cancer [ tcga ]
S341 C341 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y344 * Biomuta DOID:3571 / liver cancer [ icgc ]
R388 Q388 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:3953 / adrenal gland cancer [ tcga ]
S401 R401 Biomuta DOID:3571 / liver cancer [ icgc ]
K424 Q424 Biomuta DOID:363 / uterine cancer [ tcga ]