iPTMnet Report for Q12923 (PTPN13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12923 / PTN13_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 13
Gene Name Name: PTPN13
Synonyms:PNP1,PTP1E,PTPL1;
Organism Homo sapiens (Human)

PRO ID PR:Q12923
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 13 (human)
Definition A tyrosine-protein phosphatase non-receptor type 13 that is encoded in the genome of human.
Short Label hPTPN13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12923 (PTPN13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y102 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y254 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
Y504 Phosphorylation PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
T528 Phosphorylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
C694 Methylation IEDB 31844290
K744 Ubiquitination PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
K831 Acetylation PhosphoSitePlus
T838 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
C854 Methylation IEDB 31844290
C861 Methylation IEDB 31844290
S887 Phosphorylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus   UniProt 23186163
S897 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus   UniProt 23186163
T909 Phosphorylation PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
T916 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
Y943 Phosphorylation PhosphoSitePlus
K956 Acetylation PhosphoSitePlus
K968 Acetylation PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
K983 Acetylation PhosphoSitePlus
K1002 Acetylation PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1033 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1041 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1085 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1086 Phosphorylation PhosphoSitePlus
Y1102 Phosphorylation PhosphoSitePlus
S1187 Phosphorylation PhosphoSitePlus
T1188 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
Y1328 Phosphorylation PhosphoSitePlus
S1343 Phosphorylation PhosphoSitePlus
T1355 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus
S1454 Phosphorylation PhosphoSitePlus
T1464 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus
S1561 Phosphorylation PhosphoSitePlus
S1566 Phosphorylation PhosphoSitePlus
T1577 Phosphorylation PhosphoSitePlus
T1602 Phosphorylation PhosphoSitePlus
S1629 Phosphorylation PhosphoSitePlus
S1630 Phosphorylation PhosphoSitePlus
S1824 Phosphorylation PhosphoSitePlus
K1836 Ubiquitination PhosphoSitePlus
S1954 O-Glycosylation GlyGen 29237092
S1957 O-Glycosylation GlyGen 29237092
S1972 Phosphorylation PhosphoSitePlus
S1973 Phosphorylation PhosphoSitePlus
S2032 Phosphorylation PhosphoSitePlus
S2107 Phosphorylation PhosphoSitePlus
S2171 Phosphorylation PhosphoSitePlus
R2205 Methylation PhosphoSitePlus
Y2243 Phosphorylation PhosphoSitePlus
Y2249 Phosphorylation PhosphoSitePlus
T2330 Phosphorylation PhosphoSitePlus
T2331 Phosphorylation PhosphoSitePlus
S2334 Phosphorylation PhosphoSitePlus
S2383 Phosphorylation PhosphoSitePlus
S2393 Phosphorylation PhosphoSitePlus
Y2394 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S890 Phosphorylation HPRD 19664994, 19664995
S908 Phosphorylation HPRD 19413330, 19664995
S911 Phosphorylation HPRD 19413330
S1086 Phosphorylation HPRD 19664994
S1514 Phosphorylation HPRD 19664994
S1629 Phosphorylation HPRD 19413330
S2383 Phosphorylation HPRD 18452278
S2393 Phosphorylation HPRD 18452278
Y2394 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S895 Phosphorylation HPRD 19664994
S1323 Phosphorylation HPRD 19664994
S1438 Phosphorylation HPRD 19413330
S2192 Phosphorylation HPRD 18452278
S2202 Phosphorylation HPRD 18452278
Y2203 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S890 Phosphorylation HPRD   PhosphoSitePlus 19664994, 19664995
S897 Phosphorylation PhosphoSitePlus
S908 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19664995
S911 Phosphorylation HPRD 19413330
S1041 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus
S1045 Phosphorylation PhosphoSitePlus
Y1053 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation HPRD 19664994
S1495 Phosphorylation HPRD 19664994
S1610 Phosphorylation HPRD 19413330
S2364 Phosphorylation HPRD 18452278
S2374 Phosphorylation HPRD 18452278
Y2375 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S890 Phosphorylation HPRD 19664994, 19664995
S908 Phosphorylation HPRD 19413330, 19664995
S911 Phosphorylation HPRD 19413330
S1086 Phosphorylation HPRD 19664994
S1519 Phosphorylation HPRD 19664994
S1634 Phosphorylation HPRD 19413330
S2388 Phosphorylation HPRD 18452278
S2398 Phosphorylation HPRD 18452278
Y2399 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S512 F512 Biomuta DOID:4159 / skin cancer [ cosmic ]
T838 I838 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S887 L887 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S911 C911 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T916 I916 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1014 C1014 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1026 Y1026 Biomuta DOID:363 / uterine cancer [ icgc ]
S1041 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1044 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1063 N1063 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1066 Y1066 Biomuta DOID:363 / uterine cancer [ icgc ]
S1082 N1082 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1085 Y1085 Biomuta DOID:363 / uterine cancer [ icgc ]
S1187 Y1187 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]
S1358 L1358 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1438 I1438 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S1454 C1454 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1464 I1464 Biomuta DOID:4362 / cervical cancer [ icgc ]
S1566 F1566 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S1610 I1610 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S1629 I1629 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1634 I1634 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S1824 C1824 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1954 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2107 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2171 F2171 Biomuta DOID:4159 / skin cancer [ cosmic ]
R2205 W2205 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R2205 Q2205 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]