iPTMnet Report for Q12906 (ILF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12906 / ILF3_HUMAN
Protein Name Interleukin enhancer-binding factor 3
Gene Name Name: ILF3
Synonyms:DRBF,MPHOSPH4,NF90;
Organism Homo sapiens (Human)

PRO ID PR:Q12906
DAG View
PRO Name interleukin enhancer-binding factor 3 (human)
Definition An interleukin enhancer-binding factor 3 that is encoded in the genome of human.
Short Label hILF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12906 (ILF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S57 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S62 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 24275569, 20068231
S73 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus   UniProt 19608861
K100 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus   UniProt 21123651
S190 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...20068231
K202 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
C226 Methylation IEDB 31844290
C237 Methylation IEDB 31844290
K257 Ubiquitination PhosphoSitePlus
S258 O-Glycosylation GlyGen 23301498, 30444036, 32522876, ...30397120, 30379171, 34725712, 33214551, 21740066, 33465208, 34019948, 35083852, 20305658, 32119511, 28510447, 22121020, 34229054
S258 Phosphorylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
R273 Methylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus   UniProt 34110282
T300 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus   UniProt 21123651
R323 Methylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K348 Sumoylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
T363 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T364 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
Y365 Phosphorylation phospho.ELM 18669648
T368 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
S382 O-Glycosylation GlyGen 23301498, 30444036, 32522876, ...30397120, 30379171, 34725712, 33214551, 21740066, 33465208, 34019948, 35083852, 20305658, 32119511, 28510447, 22121020, 34229054
S382 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17287340, 17081983, ...16094384, 32123579, 18669648, 31772275, 23186163, 18847512, 20068231
S384 O-Glycosylation GlyGen 33465208
S384 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18847512, 17287340, 20068231
K413 Acetylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K419 Methylation PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K460 Acetylation PhosphoSitePlus   UniProt 19608861
T469 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S476 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...24275569
S477 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S482 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17081983, 18669648, ...24275569, 21401756, 19690332, 20068231
T486 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
K489 Sumoylation PhosphoSitePlus
S503 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T504 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S506 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K540 Acetylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y579 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K587 Acetylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
T592 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 32387766, 19690332, 20068231, 17081983
K600 Acetylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K601 Acetylation PhosphoSitePlus
R609 Methylation PhosphoSitePlus
K613 Methylation PhosphoSitePlus
R640 Methylation PhosphoSitePlus
R642 Methylation PhosphoSitePlus
S647 Phosphorylation P31749 (AKT1) , P05771 (PRKCB) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18097023, 26891316, 20870937
Y665 Phosphorylation PhosphoSitePlus
Y672 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
K734 Acetylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Y767 Phosphorylation PhosphoSitePlus
Y777 Phosphorylation PhosphoSitePlus
Y784 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
Y786 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
Y790 Phosphorylation PhosphoSitePlus
S792 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S799 Phosphorylation PhosphoSitePlus
Y801 Phosphorylation PhosphoSitePlus
Y803 Phosphorylation PhosphoSitePlus
Y809 Phosphorylation PhosphoSitePlus
S810 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S812 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
R815 Methylation PhosphoSitePlus
S816 Phosphorylation PhosphoSitePlus   UniProt 23186163
S820 Phosphorylation PhosphoSitePlus
Y821 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
S827 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y828 Phosphorylation PhosphoSitePlus
S832 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y836 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
Y846 Phosphorylation PhosphoSitePlus
Y853 Phosphorylation PhosphoSitePlus
Y858 Phosphorylation PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
Y867 Phosphorylation PhosphoSitePlus
Y874 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
R883 Methylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
Y891 Phosphorylation PhosphoSitePlus
Y893 Phosphorylation PhosphoSitePlus
R894 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 18669648, 18452278
S62 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 18452278
S190 Phosphorylation HPRD 18669648, 17081983, 20068231
S362 Phosphorylation HPRD 20068231
T364 Phosphorylation HPRD 18669648, 20068231
Y365 Phosphorylation HPRD 18669648
T368 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S382 Phosphorylation HPRD 17287340, 16094384, 18767875, ...18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 20068230
S384 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18707149, 20068231, 20068230
T469 Phosphorylation HPRD 17081983, 20068231
S476 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S477 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 20068231
S482 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 20068231
T486 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S503 Phosphorylation HPRD 18669648, 20068231
T504 Phosphorylation HPRD 19413330, 18669648
S511 Phosphorylation HPRD 17081983
T522 Phosphorylation HPRD 17081983, 20068231
S571 Phosphorylation HPRD 20068231
Y579 Phosphorylation HPRD 18669648
T592 Phosphorylation HPRD 19413330, 20058876, 15302935, ...19664994, 19664995, 19651622, 18669648, 19415658, 20068231, 17924679
Y665 Phosphorylation HPRD 20068231
Y672 Phosphorylation HPRD 20068231
S674 Phosphorylation HPRD 20068231
Y675 Phosphorylation HPRD 20068231
S681 Phosphorylation HPRD 20068231
S710 Phosphorylation HPRD 20068231
S715 Phosphorylation HPRD 20068231
S762 Phosphorylation HPRD 20068231
S792 Phosphorylation HPRD 19413330, 18669648, 20068231
S810 Phosphorylation HPRD 19651622, 18669648, 20068231
S812 Phosphorylation HPRD 19651622, 18669648, 20068231, ...17924679
S827 Phosphorylation HPRD 18669648
S832 Phosphorylation HPRD 18669648
S860 Phosphorylation HPRD 19413330
S877 Phosphorylation HPRD 18077418
S888 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 18669648, 18452278
S62 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 18452278
S190 Phosphorylation HPRD 18669648, 17081983, 20068231
S362 Phosphorylation HPRD 20068231
T364 Phosphorylation HPRD 18669648, 20068231
Y365 Phosphorylation HPRD 18669648
T368 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S382 Phosphorylation HPRD 17287340, 16094384, 18767875, ...18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 20068230
S384 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18707149, 20068231, 20068230
T469 Phosphorylation HPRD 17081983, 20068231
S476 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S477 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 20068231
S482 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 20068231
T486 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S503 Phosphorylation HPRD 18669648, 20068231
T504 Phosphorylation HPRD 19413330, 18669648
S511 Phosphorylation HPRD 17081983
T522 Phosphorylation HPRD 17081983, 20068231
S571 Phosphorylation HPRD 20068231
Y579 Phosphorylation HPRD 18669648
T592 Phosphorylation HPRD 19413330, 20058876, 15302935, ...19664994, 19664995, 19651622, 18669648, 19415658, 20068231, 17924679
Y694 Phosphorylation PhosphoSitePlus
Y696 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation phospho.ELM 18669648
S62 Phosphorylation phospho.ELM 18669648
S190 Phosphorylation phospho.ELM 18669648
T364 Phosphorylation phospho.ELM 18669648
Y365 Phosphorylation phospho.ELM 18669648
T368 Phosphorylation phospho.ELM 18669648
S382 Phosphorylation phospho.ELM 18669648
T469 Phosphorylation phospho.ELM 18669648
S476 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S477 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S482 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T486 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S503 Phosphorylation phospho.ELM 18669648
T504 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S506 Phosphorylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K591 Acetylation PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 18669648, 18452278
S62 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231, 18452278
S190 Phosphorylation HPRD 18669648, 17081983, 20068231
S362 Phosphorylation HPRD 20068231
T364 Phosphorylation HPRD 18669648, 20068231
Y365 Phosphorylation HPRD 18669648
T368 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S382 Phosphorylation HPRD 17287340, 16094384, 18767875, ...18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 20068230
S384 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18707149, 20068231, 20068230
T469 Phosphorylation HPRD 17081983, 20068231
S476 Phosphorylation HPRD 18669648, 18452278, 19664995, ...20068231, 17081983
S477 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 20068231
S482 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 20068231
T486 Phosphorylation HPRD   phospho.ELM 17081983, 18220336, 19664995, ...18452278, 18669648, 20068231
S503 Phosphorylation HPRD 18669648, 20068231
T504 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648
S511 Phosphorylation HPRD 17081983
T522 Phosphorylation HPRD 17081983, 20068231
S571 Phosphorylation HPRD 20068231
Y579 Phosphorylation HPRD 18669648
K587 Acetylation PhosphoSitePlus
T592 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20058876, 15302935, ...19664994, 19664995, 19651622, 18669648, 19415658, 20068231, 17924679
Y672 Phosphorylation PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T504 Phosphorylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R5 Q5 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R12 L12 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R12 C12 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R12 H12 Biomuta DOID:363 / uterine cancer [ icgc ]
R12 S12 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K17 N17 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ icgc ]
K17 R17 Biomuta DOID:363 / uterine cancer [ icgc ]
Y22 C22 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S57 N57 Biomuta DOID:1612 / breast cancer [ icgc ]
S62 F62 Biomuta DOID:4159 / skin cancer [ cosmic ]
K100 N100 Biomuta DOID:1319 / brain cancer [ icgc ]
S173 F173 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T261 A261 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R273 Q273 Biomuta DOID:1319 / brain cancer [ icgc ]
K348 R348 Biomuta [ cosmic ]
T368 M368 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T504 S504 Biomuta DOID:1324 / lung cancer [ icgc ]
S506 I506 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T547 I547 Biomuta DOID:1319 / brain cancer [ cosmic ]
K601 N601 Biomuta DOID:1324 / lung cancer [ cosmic ]
R640 Q640 Biomuta DOID:2021 / placenta cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
R642 Q642 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y672 C672 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S674 N674 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y677 C677 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ icgc ]
S681 L681 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S762 R762 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y764 F764 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S765 I765 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y777 C777 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S787 L787 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R815 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S840 F840 Biomuta DOID:4159 / skin cancer [ cosmic ]
S860 F860 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S863 F863 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S876 P876 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R894 I894 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc, icgc, icgc ] DOID:1612 / breast cancer [ icgc, icgc, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc, cosmic, cosmic ] DOID:1793 / pancreatic cancer [ cosmic, cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic, cosmic, cosmic, icgc ]