iPTMnet Report for Q12884 (FAP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12884 / SEPR_HUMAN
Protein Name Prolyl endopeptidase FAP
Gene Name Name: FAP
Organism Homo sapiens (Human)

PRO ID PR:Q12884
DAG View
PRO Name prolyl endopeptidase FAP (human)
Definition A prolyl endopeptidase FAP that is encoded in the genome of human.
Short Label hFAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12884 (FAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N49 N-Glycosylation GlyGen   UniProt 23090970, 15809306, 29391424, ...24190977
N92 N-Glycosylation GlyGen   UniProt 15809306
N99 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977, ...29391424, 29741879
N227 N-Glycosylation GlyGen   UniProt 16335952, 15809306
K254 Acetylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
N314 N-Glycosylation GlyGen   UniProt 23090970, 15809306, 24190977
S551 Phosphorylation PhosphoSitePlus
Y595 Phosphorylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
N679 N-Glycosylation GlyGen 23090970, 29391424, 24190977
S680 Phosphorylation PhosphoSitePlus
T681 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N227 Y227 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T602 A602 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S680 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T681 N681 Biomuta DOID:9256 / colorectal cancer [ cosmic ]