iPTMnet Report for Q12882 (DPYD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12882 / DPYD_HUMAN
Protein Name Dihydropyrimidine dehydrogenase [NADP(+)] precursor
Gene Name Name: DPYD
Organism Homo sapiens (Human)

PRO ID PR:Q12882
DAG View
PRO Name dihydropyrimidine dehydrogenase [NADP(+)] (human)
Definition A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human.
Short Label hDPYD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12882 (DPYD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T31 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T65 O-Glycosylation GlyGen 30379171, 31492838, 35254053
T66 O-Glycosylation GlyGen 30379171, 31492838, 35254053
K81 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S260 O-Glycosylation GlyGen 30379171, 31492838, 35254053
S260 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus   UniProt 19608861
K384 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
T760 Phosphorylation IEDB 32387766
Y762 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
T768 Phosphorylation PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K888 Ubiquitination PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
K898 Methylation PhosphoSitePlus
K898 Ubiquitination PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus   UniProt 23186163
K908 Methylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 L32 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
K63 N63 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T65 M65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T66 N66 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K98 Q98 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K98 N98 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S99 L99 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S175 L175 Biomuta DOID:4159 / skin cancer [ cosmic ]
K181 E181 Biomuta DOID:4159 / skin cancer [ cosmic ]
K259 E259 Biomuta DOID:1324 / lung cancer [ cosmic ]
S260 R260 Biomuta DOID:1612 / breast cancer [ cosmic ]
K307 E307 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K307 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K365 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K381 N381 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K384 T384 Biomuta DOID:363 / uterine cancer [ icgc ]
K418 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S436 R436 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S440 L440 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K448 N448 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T575 I575 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S577 Y577 Biomuta DOID:363 / uterine cancer [ icgc ]
K580 N580 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S587 F587 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K655 N655 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K655 E655 Biomuta DOID:363 / uterine cancer [ cosmic ]
K709 R709 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K725 E725 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K758 R758 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T768 K768 Biomuta DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T768 S768 Biomuta DOID:3571 / liver cancer [ cosmic ]
K841 I841 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K875 Q875 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S905 L905 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K922 N922 Biomuta DOID:9256 / colorectal cancer [ cosmic ]