iPTMnet Report for Q12879 (GRIN2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12879 / NMDE1_HUMAN
Protein Name Glutamate receptor ionotropic, NMDA 2A precursor
Gene Name Name: GRIN2A
Synonyms:NMDAR2A;
Organism Homo sapiens (Human)

PRO ID PR:Q12879
DAG View
PRO Name glutamate receptor ionotropic, NMDA 2A (human)
Definition A glutamate receptor ionotropic, NMDA 2A that is encoded in the genome of human.
Short Label hGRIN2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12879 (GRIN2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C87 S-Nitrosylation dbSNO 12183209, 17196530, 22178444, ...17434127
T104 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
C320 S-Nitrosylation dbSNO 12183209, 17196530, 22178444, ...17434127
N380 N-Glycosylation GlyGen 24190977
Y393 Phosphorylation PhosphoSitePlus
C399 S-Nitrosylation dbSNO 12183209, 10571239, 17434127, ...10607390, 15688001, 11092448, 22178444
N444 N-Glycosylation GlyGen 24190977
T470 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
Y730 Phosphorylation PhosphoSitePlus
Y737 Phosphorylation PhosphoSitePlus
T749 Phosphorylation PhosphoSitePlus
K880 Methylation PhosphoSitePlus
S900 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus
S912 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S913 Phosphorylation PhosphoSitePlus
S917 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S929 Phosphorylation PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
Y943 Phosphorylation P06241 (FYN) PhosphoSitePlus 19834457
S944 Phosphorylation PhosphoSitePlus
Y1105 Phosphorylation P06241 (FYN) PhosphoSitePlus 19834457
Y1118 Phosphorylation P06241 (FYN) PhosphoSitePlus 19834457
S1163 Phosphorylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
S1179 Phosphorylation PhosphoSitePlus
Y1184 Phosphorylation P12931 (SRC) PhosphoSitePlus 20448061
Y1187 Phosphorylation P06241 (FYN) PhosphoSitePlus 19834457
S1232 Phosphorylation neXtProt   phospho.ELM 11675505
Y1246 Phosphorylation P06241 (FYN) PhosphoSitePlus 19834457
Y1267 Phosphorylation P06241 (FYN) , P12931 (SRC) PhosphoSitePlus 10846184, 19834457
S1291 Phosphorylation PhosphoSitePlus
Y1292 Phosphorylation PhosphoSitePlus
Y1325 Phosphorylation P06241 (FYN) , P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 20585660, 20448061, 19834457
Y1387 Phosphorylation PhosphoSitePlus   RLIMS-P 31518901
S1416 Phosphorylation RLIMS-P 11104776
Y1423 Phosphorylation P12931 (SRC) PhosphoSitePlus 20448061
S1459 Phosphorylation PhosphoSitePlus   RLIMS-P 32877683, 34233182
Site PTM Type PTM Enzyme Score Source PMID
S912 Phosphorylation HPRD 17287340
S917 Phosphorylation HPRD 17287340
Y1105 Phosphorylation P12931 (SRC) HPRD 10195142
S1232 Phosphorylation Q00535 (CDK5) HPRD 11675505
Y1267 Phosphorylation P12931 (SRC) HPRD 10846184
S1291 Phosphorylation Q9UQM7 (CAMK2A) , Q13554 (CAMK2B) HPRD 12147342
S1337 Phosphorylation HPRD 17081983
Y1387 Phosphorylation P12931 (SRC) HPRD 10195142
S1416 Phosphorylation P17252 (PRKCA) HPRD 11104776


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q12879 (GRIN2A) S1459 Q96L92 (SNX27) increased_association eFIP 34233182
Phosphorylation Q12879 (GRIN2A) Y1387 Q9Y2J0 (RPH3A) unknown eFIP 31518901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C87 F87 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C87 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T104 M104 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S262 F262 Biomuta DOID:4159 / skin cancer [ cosmic ]
S274 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S274 L274 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S278 F278 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S280 F280 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y281 * Biomuta DOID:1324 / lung cancer [ cosmic ]
N380 D380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y393 H393 Biomuta DOID:1324 / lung cancer [ cosmic ]
C399 Y399 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
C399 W399 Biomuta DOID:1324 / lung cancer [ cosmic ]
C399 R399 Biomuta DOID:1319 / brain cancer [ icgc ]
N444 Y444 Biomuta DOID:1324 / lung cancer [ cosmic ]
S719 N719 Biomuta [ cosmic ]
Y737 H737 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T749 S749 Biomuta DOID:1319 / brain cancer [ cosmic ]
S905 F905 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S908 T908 Biomuta DOID:4159 / skin cancer [ cosmic ]
S912 F912 Biomuta DOID:4159 / skin cancer [ cosmic ]
S913 L913 Biomuta DOID:1324 / lung cancer [ cosmic ]
S929 F929 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K938 M938 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y943 C943 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1105 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1163 F1163 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1164 K1164 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1164 M1164 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1179 P1179 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1179 F1179 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S1232 F1232 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1291 F1291 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1292 F1292 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1325 D1325 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1337 L1337 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y1387 * Biomuta [ cosmic ]