iPTMnet Report for Q12873 (CHD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12873 / CHD3_HUMAN
Protein Name Chromodomain-helicase-DNA-binding protein 3
Gene Name Name: CHD3
Organism Homo sapiens (Human)

PRO ID PR:Q12873
DAG View
PRO Name chromodomain-helicase-DNA-binding protein 3 (human)
Definition A chromodomain-helicase-DNA-binding protein 3 that is encoded in the genome of human.
Short Label hCHD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12873 (CHD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K56 Methylation PhosphoSitePlus
K58 Methylation PhosphoSitePlus
K64 Methylation PhosphoSitePlus
S73 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S79 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S88 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S324 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S328 Phosphorylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
Y595 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus   UniProt 23186163
K620 Ubiquitination PhosphoSitePlus
K627 Sumoylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S713 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 19690332
T715 Phosphorylation PhosphoSitePlus
K721 Sumoylation PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
T724 Phosphorylation PhosphoSitePlus
Y739 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
S795 Phosphorylation IEDB 32387766
K820 Ubiquitination PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
T866 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
K894 Acetylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
K954 Ubiquitination PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
K979 Ubiquitination PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
K997 Acetylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
Y998 Phosphorylation PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
K1044 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus
K1222 Acetylation PhosphoSitePlus
K1222 Ubiquitination PhosphoSitePlus
K1230 Ubiquitination PhosphoSitePlus
K1238 Sumoylation PhosphoSitePlus
K1238 Ubiquitination PhosphoSitePlus
K1246 Ubiquitination PhosphoSitePlus
T1274 Phosphorylation PhosphoSitePlus
Y1282 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
S1285 Phosphorylation PhosphoSitePlus
K1287 Ubiquitination PhosphoSitePlus
K1298 Ubiquitination PhosphoSitePlus
K1308 Sumoylation PhosphoSitePlus
K1308 Ubiquitination PhosphoSitePlus
Y1317 Phosphorylation PhosphoSitePlus
K1320 Ubiquitination PhosphoSitePlus
R1323 Methylation PhosphoSitePlus
K1339 Ubiquitination PhosphoSitePlus
S1361 Phosphorylation PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus
S1367 Phosphorylation PhosphoSitePlus   UniProt 18669648
K1394 Sumoylation PhosphoSitePlus
K1394 Ubiquitination PhosphoSitePlus
S1528 O-Glycosylation GlyGen 34019948, 32522876, 29351928
S1532 Phosphorylation PhosphoSitePlus
S1533 Phosphorylation PhosphoSitePlus
T1535 Phosphorylation PhosphoSitePlus
K1536 Ubiquitination PhosphoSitePlus
T1537 Phosphorylation PhosphoSitePlus
T1540 Phosphorylation PhosphoSitePlus
T1541 Phosphorylation PhosphoSitePlus
S1545 Phosphorylation PhosphoSitePlus
T1547 Phosphorylation PhosphoSitePlus
S1549 Phosphorylation PhosphoSitePlus
T1552 Phosphorylation PhosphoSitePlus
S1553 Phosphorylation PhosphoSitePlus
K1554 Ubiquitination PhosphoSitePlus
T1557 Phosphorylation PhosphoSitePlus
S1561 Phosphorylation PhosphoSitePlus
T1569 Phosphorylation PhosphoSitePlus
T1595 Phosphorylation PhosphoSitePlus
S1601 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...15302935, 18669648, 24275569, 19690332, 20068231
S1605 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S1641 Phosphorylation PhosphoSitePlus
S1645 Phosphorylation PhosphoSitePlus
T1646 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1759 Methylation PhosphoSitePlus
K1782 Ubiquitination PhosphoSitePlus
S1819 Phosphorylation PhosphoSitePlus
K1848 Ubiquitination PhosphoSitePlus
S1850 Phosphorylation PhosphoSitePlus
K1855 Ubiquitination PhosphoSitePlus
S1873 Phosphorylation PhosphoSitePlus
K1876 Ubiquitination PhosphoSitePlus
T1880 Phosphorylation PhosphoSitePlus
S1899 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation HPRD 17081983
S79 Phosphorylation HPRD 17081983
Y84 Phosphorylation HPRD 17081983
S324 Phosphorylation HPRD 17081983, 18452278
S597 Phosphorylation HPRD 19651622, 18452278
S712 Phosphorylation HPRD 20068231
S713 Phosphorylation HPRD 19413330, 18691976, 15302935, ...18452278, 19651622, 18669648, 20068231
T715 Phosphorylation HPRD 18669648
T860 Phosphorylation HPRD 20068231
S861 Phosphorylation HPRD 20068231
T866 Phosphorylation HPRD 20068231
S874 Phosphorylation HPRD 20068231
S1361 Phosphorylation HPRD 18669648
S1364 Phosphorylation HPRD 18669648, 18452278
S1367 Phosphorylation HPRD 18669648, 18452278
S1549 Phosphorylation HPRD 19413330
T1569 Phosphorylation HPRD 20068231
S1601 Phosphorylation HPRD 19413330, 18691976, 18767875, ...20058876, 18452278, 17322306, 18669648, 19651622, 20068231
S1605 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation HPRD 17081983
S79 Phosphorylation HPRD 17081983
Y84 Phosphorylation HPRD 17081983
S324 Phosphorylation HPRD 17081983, 18452278
S597 Phosphorylation HPRD 19651622, 18452278
S712 Phosphorylation HPRD 20068231
S713 Phosphorylation HPRD 19413330, 18691976, 15302935, ...18452278, 19651622, 18669648, 20068231
T715 Phosphorylation HPRD 18669648
T860 Phosphorylation HPRD 20068231
S861 Phosphorylation HPRD 20068231
T866 Phosphorylation HPRD 20068231
S874 Phosphorylation HPRD 20068231
S1361 Phosphorylation HPRD 18669648
S1364 Phosphorylation HPRD 18669648, 18452278
S1367 Phosphorylation HPRD 18669648, 18452278
S1549 Phosphorylation HPRD 19413330
T1569 Phosphorylation HPRD 20068231
S1601 Phosphorylation HPRD 19413330, 18691976, 20058876, ...15302935, 18452278, 19651622, 18669648, 18767875, 20068231
S1605 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation HPRD   PhosphoSitePlus 17081983
S132 Phosphorylation HPRD 17081983
S138 Phosphorylation HPRD 17081983
Y143 Phosphorylation HPRD 17081983
K235 Acetylation PhosphoSitePlus
S383 Phosphorylation HPRD 17081983, 18452278
S656 Phosphorylation HPRD 19651622, 18452278
S771 Phosphorylation HPRD 20068231
S772 Phosphorylation HPRD 19413330, 18691976, 15302935, ...18452278, 19651622, 18669648, 20068231
T774 Phosphorylation HPRD 18669648
T919 Phosphorylation HPRD 20068231
S920 Phosphorylation HPRD 20068231
T925 Phosphorylation HPRD 20068231
S933 Phosphorylation HPRD 20068231
S1420 Phosphorylation HPRD 18669648
S1423 Phosphorylation HPRD 18669648, 18452278
S1426 Phosphorylation HPRD 18669648, 18452278
S1608 Phosphorylation HPRD 19413330
T1628 Phosphorylation HPRD 20068231
S1660 Phosphorylation HPRD 19413330, 18691976, 18767875, ...20058876, 18452278, 17322306, 18669648, 19651622, 20068231
S1664 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 N48 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y95 C95 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K302 N302 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S313 I313 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S313 R313 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T376 M376 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:4606 / bile duct cancer [ cosmic ]
S597 P597 Biomuta DOID:4159 / skin cancer [ cosmic ]
S656 P656 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y739 C739 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T860 P860 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S861 L861 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K894 N894 Biomuta DOID:1319 / brain cancer [ icgc ]
T919 P919 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S920 L920 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T1001 S1001 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1044 N1044 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1246 N1246 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1285 F1285 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1339 Q1339 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1528 F1528 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1533 P1533 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1537 M1537 Biomuta DOID:363 / uterine cancer [ icgc ]
T1557 S1557 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R1759 W1759 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1850 L1850 Biomuta DOID:1319 / brain cancer [ cosmic ]