Protein Information

Cytoscape View

UniProt AC / UniProt ID Q12866 / MERTK_HUMAN
Protein Name Tyrosine-protein kinase Mer precursor
Gene Name Name: MERTK
Organism Homo sapiens (Human)

PRO ID PR:Q12866
DAG View
PRO Name tyrosine-protein kinase Mer (human)
Definition A tyrosine-protein kinase Mer that is encoded in the genome of human.
Short Label hMERTK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q12866 (MERTK) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T45 O-Glycosylation GlyGen 30459171
T84 O-Glycosylation GlyGen 30459171
N114 N-Glycosylation GlyGen 29391424
N170 N-Glycosylation GlyGen 23090970, 29391424, 24190977
N207 N-Glycosylation GlyGen 23090970, 29741879, 29391424
N266 N-Glycosylation GlyGen 24190977
N316 N-Glycosylation GlyGen 29391424
N442 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...29391424, 24190977
N454 N-Glycosylation GlyGen 29391424, 24190977
T458 Phosphorylation HPRD   PhosphoSitePlus 19664995
S543 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y549 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
N625 N-Glycosylation GlyGen 29391424
S645 Phosphorylation PhosphoSitePlus
T699 Phosphorylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
Y749 Phosphorylation Q12866 (MERTK) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 8702477
S750 Phosphorylation PhosphoSitePlus
Y753 Phosphorylation Q12866 (MERTK) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33119085, 8702477
Y754 Phosphorylation Q12866 (MERTK) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8702477, 33119085
K761 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
R775 Methylation PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
Y872 Phosphorylation Q12866 (MERTK) neXtProt 18039660
K923 Ubiquitination PhosphoSitePlus
Y929 Phosphorylation PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus   UniProt 19369195

Q12866 (MERTK) as PTM Enzyme

Substrate Site Score Source PMID
Q12866 (MERTK) Y749 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 8702477
Q12866 (MERTK) Y753 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 8702477
Q12866 (MERTK) Y754 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 8702477
Q12866 (MERTK) Y872 neXtProt 18039660

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N454 D454 Biomuta DOID:10283 / prostate cancer [ cosmic ]
N454 S454 Biomuta DOID:0070003 / blastoma [ cosmic ]
S543 F543 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K552 N552 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K622 N622 Biomuta DOID:363 / uterine cancer [ tcga ]
Y749 C749 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S750 I750 Biomuta DOID:3571 / liver cancer [ icgc ]
R775 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S935 I935 Biomuta DOID:3571 / liver cancer [ icgc ]