iPTMnet Report for Q12857 (NFIA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12857 / NFIA_HUMAN
Protein Name Nuclear factor 1 A-type
Gene Name Name: NFIA
Synonyms:KIAA1439;
Organism Homo sapiens (Human)

PRO ID PR:Q12857
DAG View
PRO Name nuclear factor 1 A-type (human)
Definition A nuclear factor 1 A-type that is encoded in the genome of human.
Short Label hNFIA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12857 (NFIA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
S232 Phosphorylation phospho.ELM 18669648
T240 Phosphorylation phospho.ELM 18669648
S247 Phosphorylation phospho.ELM 18669648
S256 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S258 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S265 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S268 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S268 Phosphorylation PhosphoSitePlus
S270 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S270 Phosphorylation PhosphoSitePlus
S271 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S271 Phosphorylation PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
S273 Phosphorylation phospho.ELM 18669648
S274 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S280 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...24275569, 19690332, 20068231
S287 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 15302935, ...18669648, 24275569, 19690332, 20068231
Y294 Phosphorylation PhosphoSitePlus
S300 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...18669648, 24275569, 20068231
S303 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S305 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
S307 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T321 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
S329 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S332 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S332 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S333 Phosphorylation PhosphoSitePlus
S335 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S335 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T339 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S340 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
T344 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
T344 Phosphorylation PhosphoSitePlus
S360 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S360 Phosphorylation PhosphoSitePlus   UniProt 20068231
T364 Phosphorylation PhosphoSitePlus
T367 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
T372 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S373 O-Glycosylation GlyGen 34846842, 33214551, 28510447, ...30059200, 29351928, 31492838, 35289036, 35254053
S373 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R389 Methylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus   UniProt 24275569
T471 Phosphorylation PhosphoSitePlus   UniProt 24275569
S472 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S232 Phosphorylation HPRD 18669648
T234 Phosphorylation HPRD 20068231
T240 Phosphorylation HPRD 18669648
S247 Phosphorylation HPRD 18669648, 20068231
S256 Phosphorylation HPRD 18669648
S258 Phosphorylation HPRD 18669648, 20068231
S265 Phosphorylation HPRD 18669648, 19007248, 20068231
S273 Phosphorylation HPRD 18669648, 20068231
S280 Phosphorylation HPRD 20166139, 18669648, 20068231, ...18452278
S287 Phosphorylation HPRD 20166139, 18669648, 15302935, ...20068231, 18452278
S300 Phosphorylation HPRD 17525332, 18077418, 18452278, ...19651622, 18669648, 20166139, 20068231
S303 Phosphorylation HPRD 20166139, 18669648, 18452278
S305 Phosphorylation HPRD 18077418, 17525332, 18669648, ...20068231, 18452278
S319 Phosphorylation HPRD 18077418, 18669648, 20068231
T321 Phosphorylation HPRD 18452278
S332 Phosphorylation HPRD 18669648
S335 Phosphorylation HPRD 18669648
S360 Phosphorylation HPRD 20068231
T372 Phosphorylation HPRD 18669648, 20068231
S373 Phosphorylation HPRD 18669648, 20068231
S469 Phosphorylation PhosphoSitePlus
S472 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T145 I145 Biomuta DOID:4159 / skin cancer [ cosmic ]
S247 L247 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S265 F265 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
T275 R275 Biomuta DOID:1324 / lung cancer [ cosmic ]
S287 R287 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y294 H294 Biomuta DOID:4159 / skin cancer [ cosmic ]
S300 F300 Biomuta DOID:4159 / skin cancer [ cosmic ]
S340 F340 Biomuta DOID:4159 / skin cancer [ cosmic ]
S469 P469 Biomuta DOID:3565 / meningioma [ cosmic ]
Y475 C475 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ icgc ]