iPTMnet Report for Q12851 (MAP4K2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12851 / M4K2_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase kinase 2
Gene Name Name: MAP4K2
Synonyms:GCK,RAB8IP;
Organism Homo sapiens (Human)

PRO ID PR:Q12851
DAG View
PRO Name mitogen-activated protein kinase kinase kinase kinase 2 (human)
Definition A mitogen-activated protein kinase kinase kinase kinase 2 that is encoded in the genome of human.
Short Label hMAP4K2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12851 (MAP4K2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus   UniProt 23186163
K336 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...19690332
K403 Ubiquitination PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
C481 Methylation IEDB 31844290
S542 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
T578 Phosphorylation PhosphoSitePlus
K591 Ubiquitination PhosphoSitePlus
C598 Methylation IEDB 31844290
T819 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation HPRD 19413330
S394 Phosphorylation HPRD 18669648


Q12851 (MAP4K2) as PTM Enzyme



Substrate Site Score Source PMID
P02810 (PRH2) S24 phospho.ELM   PhosphoSitePlus 10684652


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 N48 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S170 F170 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T326 I326 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S328 L328 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S385 L385 Biomuta DOID:4159 / skin cancer [ cosmic ]
C481 Y481 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T578 I578 Biomuta DOID:4159 / skin cancer [ cosmic ]
K591 N591 Biomuta DOID:363 / uterine cancer [ icgc ]
T819 S819 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]