Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12840 / KIF5A_HUMAN
Protein Name Kinesin heavy chain isoform 5A
Gene Name Name: KIF5A
Synonyms:NKHC1;
Organism Homo sapiens (Human)

PRO ID PR:Q12840
DAG View
PRO Name kinesin heavy chain isoform 5A (human)
Definition A kinesin heavy chain isoform 5A that is encoded in the genome of human.
Short Label hKIF5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12840 (KIF5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
T152 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T806 Phosphorylation PhosphoSitePlus
T807 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K883 Acetylation PhosphoSitePlus
K888 Acetylation PhosphoSitePlus
K890 Acetylation PhosphoSitePlus
R899 Methylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T170 S170 Biomuta DOID:1612 / breast cancer [ cosmic ]
T170 A170 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K253 N253 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T298 M298 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
T806 K806 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S831 F831 Biomuta DOID:10283 / prostate cancer [ clinvar, cosmic ]
K842 N842 Biomuta DOID:363 / uterine cancer [ tcga ]
R899 S899 Biomuta DOID:1324 / lung cancer [ tcga ]
R899 H899 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
R899 C899 Biomuta DOID:363 / uterine cancer [ tcga ]