iPTMnet Report for Q12809 (KCNH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12809 / KCNH2_HUMAN
Protein Name Potassium voltage-gated channel subfamily H member 2
Gene Name Name: KCNH2
Synonyms:ERG,ERG1,HERG;
Organism Homo sapiens (Human)

PRO ID PR:Q12809
DAG View
PRO Name potassium voltage-gated channel subfamily H member 2 (human)
Definition A voltage-gated potassium channel KCNH2 that is encoded in the genome of human.
Short Label hKCNH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12809 (KCNH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K166 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus   UniProt 23186163
S250 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S283 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10837251, 11953308, 10488078
S283 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10837251, 10488078
S284 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S322 Phosphorylation PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus
N598 N-Glycosylation GlyGen   UniProt 12063277
Y611 Phosphorylation PhosphoSitePlus
N629 N-Glycosylation GlyGen 12063277, 9925876
K741 Ubiquitination PhosphoSitePlus
Y780 Phosphorylation PhosphoSitePlus
Y827 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus   UniProt 23186163
S882 Phosphorylation PhosphoSitePlus
S890 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 10837251, 10488078, 22653970
S890 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 22653970
S890 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10837251, 10488078
T895 Phosphorylation neXtProt   PhosphoSitePlus   Signor 10837251, 10488078
T895 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10837251, 10488078
Y1009 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
S1137 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10837251, 11953308, 23186163, ...10488078
S1137 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 10837251, 10488078
Site PTM Type PTM Enzyme Score Source PMID
S283 Phosphorylation HPRD 11953308
S283 Phosphorylation P17612 (PRKACA) HPRD 11953308
N598 N-Glycosylation PRO 12063277
S1137 Phosphorylation HPRD 19651622, 10837251, 11953308
S1137 Phosphorylation P17612 (PRKACA) HPRD 19651622, 10837251, 11953308
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S797 Phosphorylation HPRD 19651622, 10837251, 11953308
S797 Phosphorylation P17612 (PRKACA) HPRD 19651622, 10837251, 11953308
Site PTM Type PTM Enzyme Score Source PMID
S283 Phosphorylation HPRD 11953308
S283 Phosphorylation P17612 (PRKACA) HPRD 11953308


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y780 F780 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S890 F890 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T895 M895 Biomuta DOID:10534 / stomach cancer [ cosmic ]