Protein Information

Cytoscape View

UniProt AC / UniProt ID Q12800 / TFCP2_HUMAN
Protein Name Alpha-globin transcription factor CP2
Gene Name Name: TFCP2
Organism Homo sapiens (Human)

PRO ID PR:Q12800
DAG View
PRO Name alpha-globin transcription factor CP2 (human)
Definition An alpha-globin transcription factor CP2 that is encoded in the genome of human.
Short Label hTFCP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q12800 (TFCP2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K50 Sumoylation PhosphoSitePlus
R98 Methylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
T258 Phosphorylation P24941 (CDK2) PhosphoSitePlus 19237534
S289 Phosphorylation P24941 (CDK2) PhosphoSitePlus 19237534
S291 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P24941 (CDK2) PhosphoSitePlus   Signor 19237534
S309 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , Q00526 (CDK3) , P24941 (CDK2) neXtProt   PhosphoSitePlus   Signor 19237534
S343 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus   UniProt 24275569
K359 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y131 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R98 Q98 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R98 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ]
K114 E114 Biomuta DOID:1909 / melanoma [ cosmic ]
Y131 H131 Biomuta DOID:363 / uterine cancer [ tcga ]
K181 N181 Biomuta DOID:1612 / breast cancer [ tcga ]
T258 A258 Biomuta DOID:9256 / colorectal cancer [ tcga ]