iPTMnet Report for Q12792 (TWF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12792 / TWF1_HUMAN
Protein Name Twinfilin-1
Gene Name Name: TWF1
Synonyms:PTK9;
Organism Homo sapiens (Human)

PRO ID PR:Q12792
DAG View
PRO Name twinfilin-1 (human)
Definition A twinfilin-1 that is encoded in the genome of human.
Short Label hTWF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12792 (TWF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K136 Acetylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 20068231, 24275569
T148 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus   UniProt 15592455, 19690332
S322 Phosphorylation PhosphoSitePlus
K325 Acetylation PhosphoSitePlus
K327 Acetylation PhosphoSitePlus
R340 Methylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus   UniProt 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K118 T118 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K135 N135 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K327 Q327 Biomuta DOID:3571 / liver cancer [ cosmic ]