iPTMnet Report for Q12789 (GTF3C1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12789 / TF3C1_HUMAN
Protein Name General transcription factor 3C polypeptide 1
Gene Name Name: GTF3C1
Organism Homo sapiens (Human)

PRO ID PR:Q12789
DAG View
PRO Name general transcription factor 3C polypeptide 1 (human)
Definition A general transcription factor 3C polypeptide 1 that is encoded in the genome of human.
Short Label hGTF3C1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12789 (GTF3C1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K107 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
C179 Methylation IEDB 31844290
K203 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S263 O-Glycosylation GlyGen 30379171, 34725712, 29351928
T275 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
C286 Methylation IEDB 31844290
Y294 Phosphorylation PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
T326 O-Glycosylation GlyGen 30620550
K337 Ubiquitination PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K496 Acetylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
C544 Methylation IEDB 31844290
S546 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus   UniProt 21406692, 21851590
S667 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K685 Ubiquitination PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
S739 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...21406692, 18669648
S746 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus
S751 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S754 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
T774 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K796 Ubiquitination PhosphoSitePlus
K833 Sumoylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
Y961 Phosphorylation PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
K989 Ubiquitination PhosphoSitePlus
T1048 Phosphorylation PhosphoSitePlus
S1062 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692, ...20068231
S1063 Phosphorylation PhosphoSitePlus
T1064 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1068 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 19690332, 20068231
S1073 Phosphorylation PhosphoSitePlus
K1090 Ubiquitination PhosphoSitePlus
K1128 Ubiquitination PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
T1146 Phosphorylation PhosphoSitePlus
T1153 O-Glycosylation GlyGen 30379171, 34725712, 29351928
S1168 Phosphorylation PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
C1188 Methylation IEDB 31844290
S1202 Phosphorylation PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
S1253 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1286 Acetylation IEDB 34357683
K1286 Ubiquitination PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
K1311 Ubiquitination PhosphoSitePlus
S1313 Phosphorylation PhosphoSitePlus
K1325 Ubiquitination PhosphoSitePlus
K1334 Ubiquitination PhosphoSitePlus
C1336 Methylation IEDB 31844290
Y1341 Phosphorylation PhosphoSitePlus
K1344 Ubiquitination PhosphoSitePlus
K1361 Ubiquitination PhosphoSitePlus
K1368 Ubiquitination PhosphoSitePlus
K1373 Ubiquitination PhosphoSitePlus
K1377 Ubiquitination PhosphoSitePlus
K1409 Ubiquitination PhosphoSitePlus
T1436 Phosphorylation PhosphoSitePlus
K1473 Ubiquitination PhosphoSitePlus
T1485 Phosphorylation PhosphoSitePlus
K1489 Ubiquitination PhosphoSitePlus
C1520 Methylation IEDB 31844290
K1535 Ubiquitination PhosphoSitePlus
R1541 Methylation PhosphoSitePlus
S1605 Phosphorylation PhosphoSitePlus
K1608 Ubiquitination PhosphoSitePlus
S1611 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1629 Ubiquitination PhosphoSitePlus
S1632 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K1636 Ubiquitination PhosphoSitePlus
T1643 Phosphorylation PhosphoSitePlus
S1653 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 20068231
K1676 Ubiquitination PhosphoSitePlus
S1767 Phosphorylation PhosphoSitePlus
K1771 Ubiquitination PhosphoSitePlus
K1820 Ubiquitination PhosphoSitePlus
S1840 O-Glycosylation GlyGen 30379171, 34725712, 29351928
S1845 Phosphorylation PhosphoSitePlus
S1854 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S1856 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S1865 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S1868 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 19690332, 20068231
T1873 Phosphorylation PhosphoSitePlus
T1878 Phosphorylation PhosphoSitePlus
T1881 Phosphorylation PhosphoSitePlus
S1911 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1953 Phosphorylation PhosphoSitePlus
S1962 Phosphorylation PhosphoSitePlus
S1969 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
C2046 Methylation IEDB 31844290
K2105 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S354 Phosphorylation HPRD 20068231
S739 Phosphorylation HPRD 19413330, 15302935, 18077418, ...19664994, 19651622, 18669648, 20068231
S746 Phosphorylation HPRD 18077418
S751 Phosphorylation HPRD 17525332, 18077418, 20068231, ...19664995
S756 Phosphorylation HPRD 18077418
T774 Phosphorylation HPRD 18669648
S1062 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
T1064 Phosphorylation HPRD 18669648
S1068 Phosphorylation HPRD 19413330, 15302935, 19664994, ...18452278, 19651622, 20068231
S1253 Phosphorylation HPRD 19651622
S1605 Phosphorylation HPRD 20068231
S1611 Phosphorylation HPRD 18669648, 18452278
S1632 Phosphorylation HPRD 18669648, 20068231
S1653 Phosphorylation HPRD 16964243, 15302935, 19664994, ...19007248, 19664995, 18669648, 20068231, 19691289
S1767 Phosphorylation HPRD 20068231
S1854 Phosphorylation HPRD 19651622, 18669648
S1856 Phosphorylation HPRD 18669648, 20068231, 18452278
S1865 Phosphorylation HPRD 18669648, 20068231, 18452278
S1868 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
S1969 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C179 R179 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K254 R254 Biomuta DOID:363 / uterine cancer [ cosmic ]
S263 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T275 S275 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y294 F294 Biomuta DOID:1324 / lung cancer [ cosmic ]
K324 R324 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T326 A326 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K337 N337 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K397 Q397 Biomuta DOID:4159 / skin cancer [ cosmic ]
K427 N427 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S478 L478 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S501 F501 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K517 N517 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K590 N590 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K590 Q590 Biomuta DOID:1324 / lung cancer [ cosmic ]
S667 Y667 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S746 N746 Biomuta DOID:263 / kidney cancer [ cosmic ]
S754 N754 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K796 E796 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S845 F845 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y961 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S964 L964 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1073 N1073 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1128 E1128 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1168 G1168 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1188 F1188 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1202 L1202 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1286 R1286 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K1288 N1288 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1361 E1361 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1368 Q1368 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1373 R1373 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1436 M1436 Biomuta DOID:363 / uterine cancer [ icgc ]
K1473 R1473 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1485 S1485 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1485 M1485 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1541 H1541 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1541 C1541 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S1611 N1611 Biomuta DOID:1319 / brain cancer [ icgc ]
K1636 R1636 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1653 F1653 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1676 E1676 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1771 N1771 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1845 N1845 Biomuta DOID:363 / uterine cancer [ icgc ]
S1856 I1856 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1856 G1856 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1868 G1868 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S1953 P1953 Biomuta DOID:363 / uterine cancer [ icgc ]
S1969 H1969 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1969 P1969 Biomuta DOID:3571 / liver cancer [ cosmic ]
K2105 R2105 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]