Protein Information

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UniProt AC / UniProt ID Q12778 / FOXO1_HUMAN
Protein Name Forkhead box protein O1
Gene Name Name: FOXO1
Synonyms:FKHR,FOXO1A;
Organism Homo sapiens (Human)

PRO ID PR:Q12778
DAG View
PRO Name forkhead box protein O1 (human)
Definition A forkhead box protein O1 that is encoded in the genome of human.
Short Label hFOXO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12778 (FOXO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation RLIMS-P 31308176
T24 Phosphorylation P31751 (AKT2) , P31749 (AKT1) , P11309-2 (PIM1) , PR:P31749 (hAKT1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11237865, 22384145, 21298325, ...28675664, 19887561, 11311120, 10377430, 25603236, 22928011, 18226221, 16203862, 28993609, 24112473, 31308176, 21177856, 26751215, 11570877, 28099936, 14664696, 30413788, 17303659, 11980723, 12228231, 21602511, 18593906, 11410590, 10358075, 24525530, 20596890, 10358014, 30261343, 16006742, 26600389, 27010363
S152 Phosphorylation RLIMS-P 22393355
S153 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S184 Phosphorylation RLIMS-P 22393355
K210 Ubiquitination PhosphoSitePlus
S212 Phosphorylation Q13043 (STK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21245099, 22898666, 18394876, ...18786403, 19221179
S218 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 30801864, 18786403
K222 Acetylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus   UniProt 18786403
S235 Phosphorylation PhosphoSitePlus   UniProt 18786403
K245 Acetylation PhosphoSitePlus
S246 Phosphorylation P28482 (MAPK1) neXtProt 17113751
K248 Acetylation PhosphoSitePlus
S249 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) , P24941 (CDK2) , P11802 (CDK4) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18356527, 25673854, 23469153, ...19549905, 22280365, 18408765, 17038621, 21969818
R251 Methylation PhosphoSitePlus
R253 Methylation PhosphoSitePlus
S256 Phosphorylation PR:P31749 (hAKT1) , Q13153 (PAK1) , Q16512 (PKN1) , P31749 (AKT1) , P31751 (AKT2) , P11309-2 (PIM1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24525530, 24886245, 15353558, ...20357092, 11237865, 11311120, 10377430, 24452601, 29093682, 24556689, 22928011, 24112473, 30690883, 16203862, 18593906, 28993609, 20685959, 18226221, 31308176, 21177856, 11980723, 26600389, 28099936, 21148296, 14664696, 30015961, 20596890, 18644889, 17596878, 12560069, 28981116, 16670089, 12228231, 31308441, 19483080, 10358076, 11410590, 24843827, 10358075, 25136826, 15668399, 29533017, 18319717, 15457186, 26879559, 10358014, 16006742, 16076959, 29423932, 14727512, 27010363
S261 Phosphorylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus   UniProt 20543840
K265 Acetylation PhosphoSitePlus   UniProt 20543840
K274 Acetylation PhosphoSitePlus   UniProt 20543840
S276 Phosphorylation PhosphoSitePlus
S287 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 19664994, ...18669648, 20068231
S293 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
T317 O-Glycosylation PhosphoSitePlus
S318 O-Glycosylation PhosphoSitePlus
S319 Phosphorylation PR:P31749 (hAKT1) , Q13237 (PRKG2) , P31749 (AKT1) , P11309-2 (PIM1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22393355, 26600389, 28099936, ...27602284, 14664696, 28993609, 11237865, 18226221, 10358014, 16006742, 11311120, 18593906, 28981116, 11980723, 12228231, 10358075, 24112473, 11410590, 27010363, 21177856
S322 Phosphorylation P48729 (CSNK1A1) , Q9HCP0 (CSNK1G1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11311120, 11980723
T323 Phosphorylation PhosphoSitePlus
S325 Phosphorylation P48729 (CSNK1A1) , P49841 (GSK3B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11980723
S329 Phosphorylation Q9UBE8 (NLK) , Q13627 (DYRK1A) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20061393, 11311120, 11980723
T333 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus   RLIMS-P 31308176
S394 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
S413 Phosphorylation P28482 (MAPK1) neXtProt 17113751
S416 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 17113751
S418 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 17113751
S429 Phosphorylation P28482 (MAPK1) neXtProt 17113751
S432 Phosphorylation Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 17113751
T467 Phosphorylation PhosphoSitePlus
S470 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 18669648, 17113751
T478 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM 18669648, 17113751
S505 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S509 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S550 O-Glycosylation PhosphoSitePlus
T560 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) neXtProt 17113751
K597 Acetylation PhosphoSitePlus
T648 O-Glycosylation PhosphoSitePlus
T649 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 25065674, 31308176
S651 Phosphorylation PhosphoSitePlus
S654 O-Glycosylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S249 Phosphorylation PR:P06493 (hCDK1) PRO 18356527


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027896 (hFOXO1/Phos:2) pT24,pS256,pS319 PR:P31749 (hAKT1) PRO 10358075
PR:000047446 (hFOXO1/Phos:3) pS218 PRO
PR:000027894 (hFOXO1/iso:1/Phos:1) pS249 PR:P06493 (hCDK1) PRO 18356527


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31749 (AKT1) S473 Q12778 (FOXO1) unknown eFIP 29410630
Phosphorylation Q12778 (FOXO1) T24 Q53ET0 (CRTC2) inhibited_association eFIP 22384145


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027894 (hFOXO1/iso:1/Phos:1) NOT Interaction PRO 18356527