iPTMnet Report for Q12774 (ARHGEF5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12774 / ARHG5_HUMAN
Protein Name Rho guanine nucleotide exchange factor 5
Gene Name Name: ARHGEF5
Synonyms:TIM;
Organism Homo sapiens (Human)

PRO ID PR:Q12774
DAG View
PRO Name Rho guanine nucleotide exchange factor 5 (human)
Definition A Rho guanine nucleotide exchange factor 5 that is encoded in the genome of human.
Short Label hARHGEF5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12774 (ARHGEF5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus   UniProt 18669648
C186 S-Nitrosylation dbSNO 26338901
S199 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S450 Phosphorylation PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 20068231
S452 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
Y579 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
Y641 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
T658 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
R789 Methylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
T804 Phosphorylation PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
Y836 Phosphorylation PhosphoSitePlus
T849 Phosphorylation PhosphoSitePlus
R866 Methylation PhosphoSitePlus   UniProt 24129315
T896 Phosphorylation PhosphoSitePlus
S897 Phosphorylation PhosphoSitePlus
S905 O-Glycosylation GlyGen 30059200
S908 Phosphorylation PhosphoSitePlus
S913 O-Glycosylation GlyGen 32574038
S913 Phosphorylation PhosphoSitePlus
T972 Phosphorylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1011 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1036 Phosphorylation PhosphoSitePlus
S1044 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1060 Ubiquitination PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus
S1087 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus
Y1097 Phosphorylation PhosphoSitePlus
Y1100 Phosphorylation PhosphoSitePlus
K1107 Ubiquitination PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
T1121 Phosphorylation PhosphoSitePlus
S1125 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1136 Phosphorylation PhosphoSitePlus
Y1140 Phosphorylation PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
T1163 Phosphorylation PhosphoSitePlus
S1188 Phosphorylation PhosphoSitePlus
Y1189 Phosphorylation PhosphoSitePlus
Y1273 Phosphorylation PhosphoSitePlus
T1277 Phosphorylation PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
S1286 Phosphorylation PhosphoSitePlus
K1343 Ubiquitination PhosphoSitePlus
Y1370 Phosphorylation PhosphoSitePlus
S1403 Phosphorylation PhosphoSitePlus
S1405 Phosphorylation PhosphoSitePlus
T1473 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 18669648
S15 Phosphorylation HPRD 18669648
T59 Phosphorylation HPRD 20068231
Y70 Phosphorylation HPRD 17389395
S184 Phosphorylation HPRD 18669648
S445 Phosphorylation HPRD 18669648, 16964243, 20068231
S450 Phosphorylation HPRD 18669648, 16964243, 20068231
S452 Phosphorylation HPRD 20068231
S662 Phosphorylation HPRD 18669648, 20068231
S685 Phosphorylation HPRD 20068231
Y1097 Phosphorylation HPRD 15951569
Y1100 Phosphorylation HPRD 15951569, 17389395
S1125 Phosphorylation HPRD 20068231
S1126 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231
S1394 Phosphorylation HPRD 20068231
S1405 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 C11 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S15 C15 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T74 M74 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T100 P100 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C186 Y186 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S452 L452 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S828 F828 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R866 Q866 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y1100 D1100 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1145 T1145 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]