Protein Information

Cytoscape View


UniProt AC / UniProt ID Q12770 / SCAP_HUMAN
Protein Name Sterol regulatory element-binding protein cleavage-activating protein
Gene Name Name: SCAP
Synonyms:KIAA0199;ORFNames:PSEC0227;
Organism Homo sapiens (Human)

PRO ID PR:Q12770
DAG View
PRO Name sterol regulatory element-binding protein cleavage-activating protein (human)
Definition A sterol regulatory element-binding protein cleavage-activating protein that is encoded in the genome of human.
Short Label hSCAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q12770 (SCAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S206 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S826 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus   UniProt 23186163
K842 Ubiquitination PhosphoSitePlus
S851 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S904 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S907 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y910 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus   UniProt 24275569
S943 Phosphorylation PhosphoSitePlus
S952 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
K1086 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S822 Phosphorylation HPRD 19651622, 20166139, 17081983
S826 Phosphorylation HPRD 17081983
S851 Phosphorylation HPRD 18578522, 19664994, 18669648
S904 Phosphorylation HPRD 18669648
S907 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y243 C243 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S851 G851 Biomuta DOID:3070 / malignant glioma [ tcga ]
K1086 T1086 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]