iPTMnet Report for Q10713 (PMPCA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q10713 / MPPA_HUMAN
Protein Name Mitochondrial-processing peptidase subunit alpha precursor
Gene Name Name: PMPCA
Synonyms:INPP5E,KIAA0123,MPPA;
Organism Homo sapiens (Human)

PRO ID PR:Q10713
DAG View
PRO Name mitochondrial-processing peptidase subunit alpha (human)
Definition A mitochondrial-processing peptidase subunit alpha that is encoded in the genome of human.
Short Label hPMPCA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q10713 (PMPCA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K53 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
T70 O-Glycosylation GlyGen 30379171
T71 O-Glycosylation GlyGen 30379171
R77 Methylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
C225 Methylation IEDB 31844290
K232 Ubiquitination PhosphoSitePlus
R243 Methylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K299 Acetylation PhosphoSitePlus   UniProt 19608861
K299 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
C391 Methylation IEDB 31844290
K460 Ubiquitination PhosphoSitePlus
C466 Methylation IEDB 31844290
T467 O-Glycosylation GlyGen 30379171, 28510447, 34725712
K473 Ubiquitination PhosphoSitePlus
K478 Acetylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y104 Phosphorylation HPRD 20068231
S106 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K64 N64 Biomuta DOID:3571 / liver cancer [ cosmic ]
K64 R64 Biomuta DOID:3571 / liver cancer [ cosmic ]
R77 C77 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
K126 Q126 Biomuta DOID:1324 / lung cancer [ cosmic ]
K135 N135 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K232 N232 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K269 N269 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S361 F361 Biomuta DOID:4159 / skin cancer [ cosmic ]
K473 N473 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]