Protein Information

Cytoscape View


UniProt AC / UniProt ID Q10570 / CPSF1_HUMAN
Protein Name Cleavage and polyadenylation specificity factor subunit 1
Gene Name Name: CPSF1
Synonyms:CPSF160;
Organism Homo sapiens (Human)

PRO ID PR:Q10570
DAG View
PRO Name cleavage and polyadenylation specificity factor subunit 1 (human)
Definition A cleavage and polyadenylation specificity factor subunit 1 that is encoded in the genome of human.
Short Label hCPSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q10570 (CPSF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y2 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
T321 Phosphorylation HPRD 20068231
K364 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K422 Acetylation PhosphoSitePlus
K435 Acetylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
K686 Acetylation PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
K694 Acetylation PhosphoSitePlus
T736 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S737 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
T739 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
Y748 Phosphorylation PhosphoSitePlus
S753 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S756 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
S758 Phosphorylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
S765 Phosphorylation HPRD 17081983
S766 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
K809 Acetylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
R925 Methylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus
T956 Phosphorylation PhosphoSitePlus
T1042 Phosphorylation PhosphoSitePlus
K1055 Ubiquitination PhosphoSitePlus
K1104 Ubiquitination PhosphoSitePlus
K1118 Ubiquitination PhosphoSitePlus
K1157 Ubiquitination PhosphoSitePlus
K1161 Ubiquitination PhosphoSitePlus
K1166 Ubiquitination PhosphoSitePlus
S1194 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1241 Ubiquitination PhosphoSitePlus
K1288 Ubiquitination PhosphoSitePlus
K1326 Ubiquitination PhosphoSitePlus
K1421 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S560 R560 Biomuta DOID:3571 / liver cancer [ icgc ]
T739 I739 Biomuta DOID:363 / uterine cancer [ tcga ]
S753 F753 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]