Protein Information

Cytoscape View


UniProt AC / UniProt ID Q09472 / EP300_HUMAN
Protein Name Histone acetyltransferase p300
Gene Name Name: EP300
Synonyms:P300;
Organism Homo sapiens (Human)

PRO ID PR:Q09472
DAG View
PRO Name histone acetyltransferase p300 (human)
Definition A histone acetyltransferase p300 that is encoded in the genome of human.
Short Label hEP300
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q09472 (EP300) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
S12 Phosphorylation PhosphoSitePlus   RLIMS-P 22465714
K14 Acetylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S24 Phosphorylation phospho.ELM 12590608
K77 Acetylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
S89 Phosphorylation Q05655 (PRKCD) , P17252 (PRKCA) , Q13131 (PRKAA1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11518699, 21940946, 12379484, ...23275565, 15006641, 26833564, 26983400, 11020388, 26859151, 27244239, 12590608, 16574662
S106 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20471956, 21108945
S133 Phosphorylation RLIMS-P 11755210, 9710589
R237 Methylation PhosphoSitePlus
K243 Methylation PhosphoSitePlus
S285 Phosphorylation HPRD   PhosphoSitePlus 19413330
K291 Acetylation PhosphoSitePlus
K292 Acetylation PhosphoSitePlus
T317 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 17623675
K336 Acetylation PhosphoSitePlus
K350 Acetylation PhosphoSitePlus
K373 Acetylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S384 Phosphorylation Q04759 (PRKCQ) neXtProt 18250452
K386 Acetylation PhosphoSitePlus
K404 Acetylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus   UniProt 18995842
K423 Acetylation PhosphoSitePlus   UniProt 18995842
K489 Acetylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
K569 Acetylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
R580 Methylation UniProt 11701890
K601 Acetylation PhosphoSitePlus
R604 Methylation UniProt 11701890
Y611 Phosphorylation PhosphoSitePlus
K614 Acetylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
Y620 Phosphorylation PhosphoSitePlus
Y629 Phosphorylation PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
K636 Acetylation PhosphoSitePlus   UniProt 19608861
K636 Ubiquitination PhosphoSitePlus
R705 Methylation PhosphoSitePlus
R728 Methylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
T839 Phosphorylation PhosphoSitePlus
T841 Phosphorylation PhosphoSitePlus
T845 Phosphorylation PhosphoSitePlus
T885 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T887 Phosphorylation HPRD   PhosphoSitePlus 19413330
T891 Phosphorylation PhosphoSitePlus
T938 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 17623675
K970 Acetylation PhosphoSitePlus
K977 Acetylation PhosphoSitePlus   UniProt 19608861
K981 Acetylation PhosphoSitePlus
K1001 Acetylation PhosphoSitePlus
K1006 Acetylation PhosphoSitePlus
K1020 Acetylation PhosphoSitePlus   UniProt 15632193
K1020 Sumoylation PhosphoSitePlus
K1024 Acetylation PhosphoSitePlus   UniProt 15632193
K1024 Sumoylation PhosphoSitePlus
S1037 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995, 18452278
S1038 Phosphorylation P06493 (CDK1) , P27361 (MAPK3) , P28482 (MAPK1) HPRD   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 19413330, 21406692, 23186163, ...19664994, 19664995, 18452278, 24275569, 24530506
S1044 Phosphorylation PhosphoSitePlus
K1045 Acetylation PhosphoSitePlus
K1046 Acetylation PhosphoSitePlus
K1047 Acetylation PhosphoSitePlus
Y1089 Phosphorylation PhosphoSitePlus
K1094 Acetylation PhosphoSitePlus
K1103 Acetylation PhosphoSitePlus
K1105 Acetylation PhosphoSitePlus
T1135 Phosphorylation PhosphoSitePlus
K1144 Acetylation PhosphoSitePlus
K1167 Acetylation PhosphoSitePlus
K1167 Ubiquitination PhosphoSitePlus
K1180 Acetylation PhosphoSitePlus
K1203 Acetylation PhosphoSitePlus
K1228 Acetylation PhosphoSitePlus
S1295 Phosphorylation PhosphoSitePlus
T1296 Phosphorylation PhosphoSitePlus
K1331 Acetylation PhosphoSitePlus
K1336 Acetylation PhosphoSitePlus   UniProt 17065153
K1340 Acetylation PhosphoSitePlus
K1340 Ubiquitination PhosphoSitePlus
Y1355 Phosphorylation PhosphoSitePlus
K1427 Acetylation PhosphoSitePlus
Y1446 Phosphorylation PhosphoSitePlus
K1473 Acetylation PhosphoSitePlus   UniProt 17065153
K1488 Ubiquitination PhosphoSitePlus
K1499 Acetylation Q09472 (EP300) PhosphoSitePlus   UniProt 15004546
K1499 Ubiquitination PhosphoSitePlus
K1518 Acetylation PhosphoSitePlus
K1528 Acetylation PhosphoSitePlus
T1533 Phosphorylation PhosphoSitePlus
S1534 Phosphorylation PhosphoSitePlus
K1542 Acetylation PhosphoSitePlus   UniProt 19608861, 18995842
K1546 Acetylation PhosphoSitePlus   UniProt 19608861, 18995842
K1549 Acetylation Q09472 (EP300) PhosphoSitePlus   UniProt 18995842, 15004546
K1550 Acetylation PhosphoSitePlus
K1551 Acetylation PhosphoSitePlus
K1554 Acetylation Q09472 (EP300) PhosphoSitePlus   UniProt 19608861, 15004546
K1555 Acetylation PhosphoSitePlus   UniProt 19608861
K1558 Acetylation PhosphoSitePlus   UniProt 19608861, 15004546
K1560 Acetylation Q09472 (EP300) PhosphoSitePlus   UniProt 19608861, 15004546
K1568 Acetylation PhosphoSitePlus
K1569 Acetylation PhosphoSitePlus
K1570 Acetylation PhosphoSitePlus
S1577 Phosphorylation PhosphoSitePlus
S1581 Phosphorylation PhosphoSitePlus
K1583 Acetylation PhosphoSitePlus   UniProt 19608861
K1583 Ubiquitination PhosphoSitePlus
K1590 Acetylation PhosphoSitePlus
K1590 Ubiquitination PhosphoSitePlus
T1632 Phosphorylation PhosphoSitePlus
K1637 Acetylation PhosphoSitePlus
K1637 Ubiquitination PhosphoSitePlus
K1674 Acetylation PhosphoSitePlus
K1699 Acetylation PhosphoSitePlus   UniProt 18995842
K1704 Acetylation PhosphoSitePlus   UniProt 18995842
K1707 Acetylation PhosphoSitePlus   UniProt 18995842
S1726 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1754 Phosphorylation PhosphoSitePlus
K1760 Acetylation PhosphoSitePlus
K1762 Acetylation PhosphoSitePlus
K1769 Acetylation PhosphoSitePlus
K1772 Acetylation PhosphoSitePlus
K1774 Acetylation PhosphoSitePlus
K1783 Acetylation PhosphoSitePlus
K1794 Acetylation PhosphoSitePlus
K1800 Acetylation PhosphoSitePlus
K1810 Acetylation PhosphoSitePlus
K1812 Acetylation PhosphoSitePlus
S1834 Phosphorylation P31751 (AKT2) , P31749 (AKT1) , O00141 (SGK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 23275565, 16926151, 21901101, ...19088076, 26859151, 26354606, 16024795, 11116148, 23792675
T1857 Phosphorylation HPRD   PhosphoSitePlus 19413330
T1859 Phosphorylation HPRD   PhosphoSitePlus 19413330
K1900 Acetylation PhosphoSitePlus
T1906 Phosphorylation PhosphoSitePlus
T1909 Phosphorylation PhosphoSitePlus
T1960 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 17623675
S2039 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P06493 (CDK1) PhosphoSitePlus   RLIMS-P+   RLIMS-P 24530506
R2059 Methylation PhosphoSitePlus
K2086 Acetylation PhosphoSitePlus
K2091 Acetylation PhosphoSitePlus
R2142 Methylation PhosphoSitePlus   UniProt 15731352
Y2219 Phosphorylation PhosphoSitePlus
R2226 Methylation PhosphoSitePlus
S2279 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21498542, 17623675
S2309 Phosphorylation PhosphoSitePlus
S2315 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21498542, 17623675
R2317 Methylation PhosphoSitePlus
S2320 Phosphorylation PhosphoSitePlus
S2325 Phosphorylation PhosphoSitePlus
S2326 Phosphorylation PhosphoSitePlus
S2328 Phosphorylation PhosphoSitePlus
R2330 Methylation PhosphoSitePlus
S2366 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21498542, 17623675


Q09472 (EP300) as PTM Enzyme



Substrate Site Score Source PMID
Q09472 (EP300) K1499 UniProt 15004546
Q09472 (EP300) K1549 UniProt 15004546
Q09472 (EP300) K1554 UniProt 19608861
Q09472 (EP300) K1560 UniProt 19608861


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S20 Q09472 (EP300) unknown eFIP 11258706
Phosphorylation P04637 (TP53) T18 Q09472 (EP300) unknown eFIP 11258706
Phosphorylation P17275 (JUNB) S79 Q09472 (EP300) unknown eFIP 15308641
Phosphorylation P40763 (STAT3) S727 Q09472 (EP300) unknown eFIP 11322950
Phosphorylation Q01543 (FLI1) T312 Q09472 (EP300) decreased_association eFIP 24058639
Phosphorylation Q04206 (RELA) S276 Q09472 (EP300) inhibited_association eFIP 27679610
Phosphorylation Q09472 (EP300) S89 P35222 (CTNNB1) increased_association eFIP 26833564
Phosphorylation Q09472 (EP300) S89 Q07869 (PPARA) unknown eFIP 26983400
Phosphorylation Q14457 (BECN1) S409 Q09472 (EP300) unknown eFIP 26008601
Phosphorylation Q9H9S0 (NANOG) T200 Q09472 (EP300) unknown eFIP 23708658
Phosphorylation Q9H9S0 (NANOG) T280 Q09472 (EP300) unknown eFIP 23708658


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 A12 Biomuta DOID:1324 / lung cancer [ cosmic ]
K14 Q14 Biomuta DOID:11054 / urinary bladder cancer [ icgc, tcga ]
S19 * Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S24 L24 Biomuta DOID:1612 / breast cancer [ icgc ]
S24 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
S133 A133 Biomuta DOID:1115 / sarcoma [ tcga ]
S499 T499 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R580 Q580 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:10534 / stomach cancer [ cosmic, tcga ]
R604 Q604 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y611 H611 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y629 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y630 * Biomuta DOID:263 / kidney cancer [ tcga ]
K636 E636 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
R705 Q705 Biomuta DOID:363 / uterine cancer [ tcga ]
R705 G705 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R728 W728 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S833 L833 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T845 S845 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1045 N1045 Biomuta DOID:1324 / lung cancer [ tcga ]
K1094 R1094 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K1228 N1228 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y1446 N1446 Biomuta DOID:3070 / malignant glioma [ cosmic ]
Y1446 C1446 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K1528 R1528 Biomuta DOID:263 / kidney cancer [ tcga ]
K1550 N1550 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K1554 N1554 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1560 N1560 Biomuta DOID:4362 / cervical cancer [ tcga ]
K1568 R1568 Biomuta DOID:3571 / liver cancer [ tcga ]
S1577 F1577 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1581 L1581 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K1583 E1583 Biomuta DOID:1324 / lung cancer [ tcga ]
K1760 R1760 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K1769 E1769 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1774 N1774 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K1794 E1794 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R2317 L2317 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R2317 Q2317 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R2317 W2317 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2366 N2366 Biomuta DOID:1909 / melanoma [ tcga ]