iPTMnet Report Q09013 DMPK

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q09013 / DMPK_HUMAN
Protein Name	Myotonin-protein kinase
Gene Name	Name: DMPK Synonyms:DM1PK,MDPK;
Organism	Homo sapiens (Human)

PRO ID	PR:Q09013 DAG View
PRO Name	myotonin-protein kinase (human)
Definition	A myotonin-protein kinase that is encoded in the genome of human.
Short Label	hDMPK
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q09013 (DMPK) as Substrate

Q09013

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S2	Phosphorylation		score1	PhosphoSitePlus
	K75	Ubiquitination		score1	PhosphoSitePlus
	K197	Ubiquitination		score1	PhosphoSitePlus
	T533	Phosphorylation		score1	PhosphoSitePlus
	T536	Phosphorylation		score1	PhosphoSitePlus
	S540	Phosphorylation		score1	PhosphoSitePlus
	R579	Methylation		score1	PhosphoSitePlus

Q09013 (DMPK) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O14974 (PPP1R12A)	T696	score4	HPRD neXtProt	11287000, 18212344, 18767875, ...11931630, 12600888, 12220642, 18669648, 10601309, 18077418
	P11831 (SRF)	T159	score2	PhosphoSitePlus	12809504
	P26678 (PLN)	S16	score2	neXtProt	15598648

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K75	R75	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T536	M536	Biomuta		DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]