iPTMnet Report for Q08J23 (NSUN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08J23 / NSUN2_HUMAN
Protein Name RNA cytosine C(5)-methyltransferase NSUN2
Gene Name Name: NSUN2
Synonyms:SAKI;
Organism Homo sapiens (Human)

PRO ID PR:Q08J23
DAG View
PRO Name RNA cytosine C(5)-methyltransferase NSUN2 (human)
Definition An RNA cytosine C(5)-methyltransferase NSUN2 that is encoded in the genome of human.
Short Label hNSUN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08J23 (NSUN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Acetylation PhosphoSitePlus
K28 Sumoylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K43 Sumoylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K88 Sumoylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
C93 S-Nitrosylation dbSNO 19483679
K95 Ubiquitination PhosphoSitePlus
K97 Sumoylation PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K111 Sumoylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
N130 N-Glycosylation GlyGen 29741879
K138 Ubiquitination PhosphoSitePlus
S139 Phosphorylation Q96GD4 (AURKB) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25233213, 17215513
K144 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
R256 Methylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K286 Sumoylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K369 Sumoylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K437 Sumoylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K445 Sumoylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
T449 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
T453 Phosphorylation PhosphoSitePlus
S456 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 20068231
T461 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K464 Acetylation PhosphoSitePlus
K464 Sumoylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
S475 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
C502 Methylation IEDB 31844290
K508 Acetylation PhosphoSitePlus
K511 Sumoylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K516 Sumoylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K557 Sumoylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
R568 Methylation PhosphoSitePlus
K577 Sumoylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K579 Sumoylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
K586 Acetylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
S593 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 21406692, 23186163, ...20068231
Y609 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K640 Acetylation PhosphoSitePlus
K640 Sumoylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
Y646 Phosphorylation PhosphoSitePlus
K650 Sumoylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K654 Sumoylation PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K660 Sumoylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K692 Sumoylation PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S743 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...15302935, 18669648, 24275569, 19690332, 20068231, 17081983
S751 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...15302935, 18669648, 24275569, 19690332, 17081983
T755 Phosphorylation PhosphoSitePlus
C758 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
Y51 Phosphorylation HPRD 19562805
S139 Phosphorylation Q96GD4 (AURKB) HPRD 17215513
T449 Phosphorylation HPRD 20068230
T453 Phosphorylation HPRD 19651622, 18669648
S456 Phosphorylation HPRD 19413330, 15302935, 19664994, ...19651622, 18669648, 20068231
T461 Phosphorylation HPRD 17287340, 20068231
S473 Phosphorylation HPRD 19651622, 18669648, 20068231
T583 Phosphorylation HPRD 20068231
S593 Phosphorylation HPRD 18669648, 15302935, 20068231
S724 Phosphorylation HPRD 15345747
S743 Phosphorylation HPRD 19413330, 18491316, 16964243, ...19664994, 15302935, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
S751 Phosphorylation HPRD 19413330, 16964243, 19664994, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 18212344
T755 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T81 I81 Biomuta DOID:4159 / skin cancer [ cosmic ]
K84 R84 Biomuta DOID:1319 / brain cancer [ icgc ]
K95 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K95 N95 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N130 D130 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N130 H130 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S139 L139 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S139 T139 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K229 N229 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S233 N233 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S244 F244 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K365 E365 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K497 N497 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K508 N508 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K516 E516 Biomuta DOID:3571 / liver cancer [ cosmic ]
K565 T565 Biomuta DOID:1324 / lung cancer [ cosmic ]
R568 W568 Biomuta DOID:1324 / lung cancer [ cosmic ]
R568 Q568 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R568 P568 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K640 * Biomuta DOID:1319 / brain cancer [ cosmic ]
Y646 H646 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S751 R751 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C758 Y758 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]