iPTMnet Report for Q08AM6 (VAC14)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08AM6 / VAC14_HUMAN
Protein Name Protein VAC14 homolog
Gene Name Name: VAC14
Synonyms:TAX1BP2,TRX;
Organism Homo sapiens (Human)

PRO ID PR:Q08AM6
DAG View
PRO Name protein VAC14 homolog (human)
Definition A protein VAC14 that is encoded in the genome of human.
Short Label hVAC14
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08AM6 (VAC14) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K5 Ubiquitination PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus   UniProt 18691976
K21 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S68 Phosphorylation IEDB 35494241
K70 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus   UniProt 18691976
T508 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S509 Phosphorylation PhosphoSitePlus
S517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S519 Phosphorylation PhosphoSitePlus
T520 Phosphorylation PhosphoSitePlus
Y646 Phosphorylation PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y748 Phosphorylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 18691976
Y296 Phosphorylation HPRD 18452278
T499 Phosphorylation HPRD 18691976
T508 Phosphorylation HPRD 18691976, 18669648, 20068231
S509 Phosphorylation HPRD 20068231
S517 Phosphorylation HPRD 18691976, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K21 N21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K35 N35 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S517 Y517 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T520 I520 Biomuta DOID:9256 / colorectal cancer [ cosmic ]