iPTMnet Report Q08999 RBL2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q08999 / RBL2_HUMAN
Protein Name	Retinoblastoma-like protein 2
Gene Name	Name: RBL2 Synonyms:RB2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q08999 DAG View
PRO Name	retinoblastoma-like protein 2 (human)
Definition	A retinoblastoma-like protein 2 that is encoded in the genome of human.
Short Label	hRBL2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q08999 (RBL2) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S98	Phosphorylation		score1	PhosphoSitePlus
	Y111	Phosphorylation		score1	PhosphoSitePlus
	S113	Phosphorylation		score1	PhosphoSitePlus
	T115	Phosphorylation		score1	PhosphoSitePlus
	K255	Ubiquitination		score1	PhosphoSitePlus
	K314	Ubiquitination		score1	PhosphoSitePlus
	T364	Phosphorylation		score1	PhosphoSitePlus
	S366	Phosphorylation		score1	PhosphoSitePlus
	S373	Phosphorylation		score1	PhosphoSitePlus
	K384	Ubiquitination		score1	PhosphoSitePlus
	K393	Ubiquitination		score1	PhosphoSitePlus
	T401	Phosphorylation		score4	IEDB phospho.ELM PRO PhosphoSitePlus Signor	32897882, 32387766, 11157749
	T401	Phosphorylation	P11802 (CDK4)	score3	phospho.ELM PhosphoSitePlus	11157749
	T401	Phosphorylation	Q00534 (CDK6)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T404	Phosphorylation		score1	PhosphoSitePlus
	S413	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	23186163, 11157749
	S413	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T417	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T417	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S420	O-Glycosylation		score3	GlyGen	30379171, 28580691, 28571750, ...26960196
	K443	Ubiquitination		score1	PhosphoSitePlus
	S531	Phosphorylation		score1	PhosphoSitePlus
	S543	Phosphorylation		score1	PhosphoSitePlus
	Y544	Phosphorylation		score1	PhosphoSitePlus
	S603	Phosphorylation		score1	PhosphoSitePlus
	S639	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	11042701, 11157749
	S639	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T642	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T642	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T647	Phosphorylation		score1	PhosphoSitePlus
	S659	Phosphorylation		score3	neXtProt phospho.ELM PhosphoSitePlus	12023960
	S659	Phosphorylation	Q9HC98 (NEK6)	score3	neXtProt PhosphoSitePlus	12023960
	T661	Phosphorylation		score1	PhosphoSitePlus
	S662	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	23186163, 19690332, 11157749
	S662	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T664	Phosphorylation		score1	PhosphoSitePlus
	T665	Phosphorylation		score1	PhosphoSitePlus
	Y667	Phosphorylation		score1	PhosphoSitePlus
	Y670	Phosphorylation		score1	PhosphoSitePlus
	S672	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	12435635, 19690332, 11157749
	S672	Phosphorylation	P11802 (CDK4)	score3	phospho.ELM PhosphoSitePlus	11157749
	S672	Phosphorylation	Q00534 (CDK6)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S676	Phosphorylation		score1	PhosphoSitePlus
	T678	Phosphorylation		score1	PhosphoSitePlus
	S688	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	23186163, 11157749
	S688	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S690	Phosphorylation		score1	PhosphoSitePlus
	T694	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T694	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S941	Phosphorylation		score0	RLIMS-P	29606701
	S948	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	11042701
	S952	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	11042701, 11157749
	S952	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T954	Phosphorylation		score1	PhosphoSitePlus
	T961	Phosphorylation		score1	PhosphoSitePlus
	S962	Phosphorylation		score3	phospho.ELM PhosphoSitePlus	11157749
	S966	Phosphorylation		score3	phospho.ELM PhosphoSitePlus UniProt	11042701
	S971	Phosphorylation		score3	phospho.ELM PhosphoSitePlus UniProt	11042701
	S972	Phosphorylation		score3	phospho.ELM PhosphoSitePlus UniProt	11042701
	S973	Phosphorylation		score4	phospho.ELM PhosphoSitePlus UniProt	11042701, 11157749
	T974	Phosphorylation		score3	phospho.ELM PhosphoSitePlus UniProt	11042701
	S981	Phosphorylation		score3	phospho.ELM PhosphoSitePlus UniProt	11042701
	S982	Phosphorylation		score4	phospho.ELM PhosphoSitePlus UniProt	11042701, 11157749
	T986	Phosphorylation		score3	phospho.ELM PhosphoSitePlus UniProt	11042701
	T988	Phosphorylation		score1	PhosphoSitePlus
	S995	Phosphorylation		score1	PhosphoSitePlus
	T1019	Phosphorylation		score1	PhosphoSitePlus
	S1035	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus Signor UniProt	19690332, 11157749
	S1035	Phosphorylation	P11802 (CDK4)	score3	phospho.ELM PhosphoSitePlus	11157749
	S1035	Phosphorylation	Q00534 (CDK6)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	Y1037	Phosphorylation		score1	PhosphoSitePlus
	T1042	Phosphorylation		score1	PhosphoSitePlus
	S1044	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S1044	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	Y1057	Phosphorylation		score1	PhosphoSitePlus
	S1059	Phosphorylation		score1	PhosphoSitePlus
	T1065	Phosphorylation		score1	PhosphoSitePlus
	S1068	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	23186163, 11157749
	S1068	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S1078	Phosphorylation		score1	PhosphoSitePlus
	S1080	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	23186163, 11157749
	S1080	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S1082	Phosphorylation		score1	PhosphoSitePlus
	S1090	Phosphorylation		score1	PhosphoSitePlus
	T1097	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	11157749
	T1097	Phosphorylation	P24941 (CDK2)	score3	phospho.ELM PhosphoSitePlus Signor	11157749
	S1112	Phosphorylation		score4	phospho.ELM PhosphoSitePlus Signor UniProt	12006580, 23186163, 11157749
	S1112	Phosphorylation	P24941 (CDK2)	score4	phospho.ELM PhosphoSitePlus Signor	12006580, 11157749
	S1138	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T401	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S413	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	T417	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S639	Phosphorylation		score4	HPRD PRO	19413330, 8710362, 11042701, ...11157749
	T642	Phosphorylation		score4	HPRD PRO	19413330, 8710362, 11042701, ...11157749
	S662	Phosphorylation		score4	HPRD PRO	20058876, 8710362, 11042701, ...11157749
	S672	Phosphorylation		score4	HPRD PRO	12006580, 8710362, 11042701, ...11157749
	S688	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	T694	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S948	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S952	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S962	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S966	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S971	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S972	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S973	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	T974	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S981	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S982	Phosphorylation		score4	HPRD PRO	19413330, 8710362, 11042701, ...11157749
	T986	Phosphorylation		score4	HPRD PRO	19413330, 8710362, 11042701, ...11157749
	S1035	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S1044	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S1068	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S1080	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	T1097	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749
	S1112	Phosphorylation		score4	HPRD PRO	8710362, 11042701, 11157749

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049025 (hRBL2/Phos:4)	pT401,pS672,pS1035		PRO
	PR:000036471 (hRBL2/iso:1/Phos:1)	pT401,pS413,pT417,pS639,pT642,pS662,pS672,pS688,pT694,pS948,pS952,pS962,pS966,pS973,pS982,pT986,pS1035,pS1044,pS1068,pS1080,pT1097,pS1112		PRO	11042701, 11157749, 8710362
	PR:000036472 (hRBL2/iso:1/Phos:2)	pS672		PRO	12006580
	PR:000036473 (hRBL2/iso:1/Phos:3)	pS639,pS952,pS966,pS971,pS972,pS973,pT974,pS981,pS982,pT986		PRO	11042701, 11157749, 8710362

Proteoform PPIs

	Protein 1	Relation	Protein 2	Source	PMID
	PR:000036471 (hRBL2/iso:1/Phos:1)	NOT Interaction		PRO	11157749
	PR:000036472 (hRBL2/iso:1/Phos:2)	Interaction	PR:Q13309 (hSKP2)	PRO	12006580
	PR:000036473 (hRBL2/iso:1/Phos:3)	Interaction	PR:Q16254 (hE2F4)	PRO	11042701, 11157749
	PR:Q08999-1 (hRBL2/iso:1)	Interaction		PRO	8361765

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S366	L366	Biomuta		DOID:9256 / colorectal cancer [ cosmic, icgc ]
S413	R413	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S420	F420	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S531	C531	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic ]
Y667	C667	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T694	M694	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S948	G948	Biomuta		DOID:3571 / liver cancer [ cosmic ]
S952	C952	Biomuta		DOID:2394 / ovarian cancer [ cosmic, icgc ]
S972	G972	Biomuta		DOID:1319 / brain cancer [ cosmic ]
S982	N982	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S1035	Y1035	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
S1044	F1044	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
Y1057	*	Biomuta		DOID:4159 / skin cancer [ cosmic ]
T1065	K1065	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1090	I1090	Biomuta		DOID:2394 / ovarian cancer [ cosmic, icgc ]