iPTMnet Report for Q08881 (ITK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08881 / ITK_HUMAN
Protein Name Tyrosine-protein kinase ITK/TSK
Gene Name Name: ITK
Synonyms:EMT,LYK;
Organism Homo sapiens (Human)

PRO ID PR:Q08881
DAG View
PRO Name tyrosine-protein kinase ITK/TSK (human)
Definition A tyrosine-protein kinase ITK/TSK that is encoded in the genome of human.
Short Label hITK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08881 (ITK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 19523959, 12842872, 12573241, ...17897671, 17439160
Y180 Phosphorylation P42680 (TEC) PhosphoSitePlus 12573241
Y180 Phosphorylation Q06187 (BTK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12573241
Y180 Phosphorylation Q08881 (ITK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 19523959, 12573241, 12842872, ...17897671, 17439160
Y182 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K296 Acetylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
Y512 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 31507602, 17192257, 19690332, ...23071622, 12842872, 15144186, 9312162
Y512 Phosphorylation P06239 (LCK) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12842872, 9312162, 15144186
T513 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
S565 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19690332, 17192257
S565 Phosphorylation Q08881 (ITK) HPRD 17192257
T585 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus


Q08881 (ITK) as PTM Enzyme



Substrate Site Score Source PMID
O43561 (LAT) Y200 neXtProt 12186560
O43561 (LAT) Y220 neXtProt 12186560
P10747 (CD28) Y191 HPRD   phospho.ELM   Signor 19901323, 22936936, 8992971
P10747-1 (CD28) Y206 HPRD 8992971
P10747 (CD28) Y209 HPRD   phospho.ELM   Signor 19901323, 22936936, 15144186, ...8992971
P10747-1 (CD28) Y218 HPRD   phospho.ELM   Signor 15144186, 8992971
P19174 (PLCG1) Y775 neXtProt 17420479
P19174 (PLCG1) Y783 neXtProt   PhosphoSitePlus 17148460, 17420479
P42680 (TEC) Y206 phospho.ELM   PhosphoSitePlus   Signor 12573241
P51813 (BMX) Y216 HPRD   PhosphoSitePlus 12573241
P51813 (BMX) Y224 HPRD 12573241
Q06187 (BTK) Y223 HPRD   PhosphoSitePlus 8630736, 8629002, 11598012, ...12573241, 12445832, 16497976
Q08881 (ITK) Y180 neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 19523959, 12573241, 12842872, ...17897671, 17439160
Q08881 (ITK) S565 HPRD 17192257
Q13094 (LCP2) Y173 PhosphoSitePlus 21725281
Q8TDQ0 (HAVCR2) Y265 PhosphoSitePlus 17069754
Q96LC7 (SIGLEC10) Y597 phospho.ELM   PhosphoSitePlus   Signor 11733002
Q96LC7 (SIGLEC10) Y667 phospho.ELM   PhosphoSitePlus   Signor 11733002
Q9H4E7 (DEF6) Y210 neXtProt   PhosphoSitePlus 22829599
Q9H4E7 (DEF6) Y222 neXtProt   PhosphoSitePlus 22829599


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048074 (hITK/Phos:1) pY180,pY512 PRO
PR:000048075 (hITK/Phos:2) pY512 PRO 9312162


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 Y22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T50 M50 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K52 Q52 Biomuta DOID:4159 / skin cancer [ cosmic ]
K119 T119 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K119 E119 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y120 C120 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T141 A141 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K150 E150 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K150 N150 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K154 N154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y180 * Biomuta DOID:1319 / brain cancer [ cosmic ]
Y182 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y198 F198 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S203 N203 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S223 I223 Biomuta DOID:363 / uterine cancer [ icgc ]
S224 N224 Biomuta DOID:363 / uterine cancer [ icgc ]
K242 N242 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K242 E242 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K248 N248 Biomuta DOID:4159 / skin cancer [ cosmic ]
K258 N258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y273 C273 Biomuta DOID:1324 / lung cancer [ cosmic ]
T274 A274 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T274 I274 Biomuta DOID:4159 / skin cancer [ cosmic ]
K303 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K497 N497 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S499 F499 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T504 S504 Biomuta DOID:4159 / skin cancer [ cosmic ]
T516 K516 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S565 L565 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y588 * Biomuta DOID:1324 / lung cancer [ cosmic ]