iPTMnet Report for Q08752 (PPID)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08752 / PPID_HUMAN
Protein Name Peptidyl-prolyl cis-trans isomerase D
Gene Name Name: PPID
Synonyms:CYP40,CYPD;
Organism Homo sapiens (Human)

PRO ID PR:Q08752
DAG View
PRO Name peptidyl-prolyl cis-trans isomerase D (human)
Definition A eukaryotic-type peptidyl-prolyl cis-trans isomerase D that is encoded in the genome of human.
Short Label hPPID
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08752 (PPID) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
K9 Ubiquitination PhosphoSitePlus
K43 Sumoylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
C71 Methylation IEDB 31844290
K79 Ubiquitination PhosphoSitePlus
K102 Sumoylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Sumoylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S201 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K235 Methylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
R251 Methylation PhosphoSitePlus
Y252 Phosphorylation HPRD   PhosphoSitePlus 19664994
K257 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
C275 S-Nitrosylation dbSNO 19483679
C282 S-Nitrosylation dbSNO 19483679
K283 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S287 Phosphorylation HPRD 18452278
K308 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K341 Sumoylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 A5 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K43 E43 Biomuta DOID:4159 / skin cancer [ cosmic ]
K79 T79 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K218 N218 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y365 H365 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K367 N367 Biomuta DOID:363 / uterine cancer [ icgc ]