Protein Information

Cytoscape View


UniProt AC / UniProt ID Q08499 / PDE4D_HUMAN
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Gene Name Name: PDE4D
Synonyms:DPDE3;
Organism Homo sapiens (Human)

PRO ID PR:Q08499
DAG View
PRO Name cAMP-specific 3',5'-cyclic phosphodiesterase 4D (human)
Definition A cAMP-specific 3',5'-cyclic phosphodiesterase 4D that is encoded in the genome of human.
Short Label hPDE4D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q08499 (PDE4D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
S20 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
T25 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S190 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S195 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
Y199 Phosphorylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
S214 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S252 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 21406692
S301 Phosphorylation PhosphoSitePlus   UniProt 21406692
K307 Ubiquitination PhosphoSitePlus
K309 Methylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S348 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
K358 Ubiquitination PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus   UniProt 23186163
K387 Sumoylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S715 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus   Signor 16973330, 10828059, 10022832
S746 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation P17612 (PRKACA) HPRD   PhosphoSitePlus 15182229, 8663227, 9639573
S35 Phosphorylation HPRD 20068231
S38 Phosphorylation HPRD 20068231
S54 Phosphorylation P17612 (PRKACA) HPRD   PhosphoSitePlus 18212344, 9639573, 8663227, ...16973330, 20068231
S61 Phosphorylation HPRD 16964243, 18212344
S66 Phosphorylation HPRD 19651622, 16964243, 20068231
S69 Phosphorylation HPRD 17081983
S71 Phosphorylation HPRD 17081983
S74 Phosphorylation HPRD 17081983, 20068231
S75 Phosphorylation HPRD 20068231
T88 Phosphorylation HPRD 17081983
S96 Phosphorylation HPRD 17081983
S212 Phosphorylation HPRD 18691976, 20068231
S239 Phosphorylation HPRD   PhosphoSitePlus 20068231
S460 Phosphorylation HPRD 20068231
S579 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) PhosphoSitePlus   Signor 11030732, 16973330, 10828059, ...10022832
S616 Phosphorylation HPRD 19651622
S618 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
K31 Acetylation PhosphoSitePlus
S490 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 10828059
Site PTM Type PTM Enzyme Score Source PMID
S413 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 10828059
Site PTM Type PTM Enzyme Score Source PMID
K42 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
S126 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 23826796
S133 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K323 Sumoylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K42 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S126 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 12023945
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S174 F174 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S195 T195 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y199 C199 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S252 R252 Biomuta DOID:3571 / liver cancer [ icgc ]
S262 T262 Biomuta DOID:363 / uterine cancer [ tcga ]
S299 Y299 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T317 N317 Biomuta DOID:363 / uterine cancer [ cosmic ]
S330 * Biomuta DOID:1909 / melanoma [ tcga ]
S348 F348 Biomuta DOID:1612 / breast cancer [ cosmic ]
K387 N387 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S606 F606 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S715 N715 Biomuta DOID:10534 / stomach cancer [ icgc ]