iPTMnet Report for Q08499 (PDE4D)
Protein Information
UniProt AC / UniProt ID | Q08499 / PDE4D_HUMAN |
Protein Name | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
Gene Name | Name: PDE4D Synonyms:DPDE3; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q08499 |
PRO Name | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (human) |
Definition | A cAMP-specific 3',5'-cyclic phosphodiesterase 4D that is encoded in the genome of human. |
Short Label | hPDE4D |
Category | organism-gene |
Q08499 (PDE4D) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S18 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18088087 | ||
S20 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18088087 | ||
T25 | Phosphorylation | score1 | PhosphoSitePlus | |||
H54 | Phosphorylation | score2 | UniProt | 15131123 | ||
P59 | Phosphorylation | score1 | UniProt | 18669648 | ||
P63 | Phosphorylation | score1 | UniProt | 18669648 | ||
S142 | Phosphorylation | score1 | PhosphoSitePlus | |||
S171 | Phosphorylation | score1 | PhosphoSitePlus | |||
S174 | Phosphorylation | score1 | PhosphoSitePlus | |||
S190 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18220336 | ||
S195 | Phosphorylation | score1 | PhosphoSitePlus | |||
S197 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16964243 | ||
Y199 | Phosphorylation | score1 | PhosphoSitePlus | |||
S202 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16964243 | ||
S214 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17081983 | ||
S252 | Phosphorylation | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score1 | PhosphoSitePlus | |||
S262 | Phosphorylation | score1 | PhosphoSitePlus | |||
S299 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S301 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
K307 | Ubiquitination | score1 | PhosphoSitePlus | |||
K309 | Methylation | score1 | PhosphoSitePlus | |||
T317 | Phosphorylation | score1 | PhosphoSitePlus | |||
S325 | Phosphorylation | score1 | PhosphoSitePlus | |||
S330 | Phosphorylation | score1 | PhosphoSitePlus | |||
S334 | Phosphorylation | score1 | PhosphoSitePlus | |||
K340 | Ubiquitination | score1 | PhosphoSitePlus | |||
S348 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 23186163, 17081983 | ||
K358 | Ubiquitination | score1 | PhosphoSitePlus | |||
S362 | Phosphorylation | score1 | PhosphoSitePlus | |||
S365 | Phosphorylation | score1 | PhosphoSitePlus | |||
S375 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K387 | Sumoylation | score1 | PhosphoSitePlus | |||
K387 | Ubiquitination | score1 | PhosphoSitePlus | |||
K396 | Ubiquitination | score1 | PhosphoSitePlus | |||
K556 | Ubiquitination | score1 | PhosphoSitePlus | |||
S576 | Phosphorylation | score1 | PhosphoSitePlus | |||
S596 | Phosphorylation | score1 | PhosphoSitePlus | |||
S597 | Phosphorylation | score1 | PhosphoSitePlus | |||
S606 | Phosphorylation | score1 | PhosphoSitePlus | |||
S657 | Phosphorylation | score1 | PhosphoSitePlus | |||
S715 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score4 | PhosphoSitePlus Signor | 16973330, 10828059, 10022832 | |
S746 | Phosphorylation | score1 | PhosphoSitePlus | |||
S761 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S13 | Phosphorylation | P17612 (PRKACA) | score4 | HPRD PhosphoSitePlus | 15182229, 8663227, 9639573 | |
S35 | Phosphorylation | score0 | HPRD | 20068231 | ||
S38 | Phosphorylation | score0 | HPRD | 20068231 | ||
S54 | Phosphorylation | P17612 (PRKACA) | score4 | HPRD PhosphoSitePlus | 18212344, 9639573, 8663227, ... | |
S61 | Phosphorylation | score0 | HPRD | 16964243, 18212344 | ||
S66 | Phosphorylation | score0 | HPRD | 19651622, 16964243, 20068231 | ||
S69 | Phosphorylation | score0 | HPRD | 17081983 | ||
S71 | Phosphorylation | score0 | HPRD | 17081983 | ||
S74 | Phosphorylation | score0 | HPRD | 17081983, 20068231 | ||
S75 | Phosphorylation | score0 | HPRD | 20068231 | ||
T88 | Phosphorylation | score0 | HPRD | 17081983 | ||
S96 | Phosphorylation | score0 | HPRD | 17081983 | ||
S212 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
S239 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
S460 | Phosphorylation | score0 | HPRD | 20068231 | ||
S579 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | score4 | PhosphoSitePlus Signor | 11030732, 16973330, 10828059, ... | |
S616 | Phosphorylation | score0 | HPRD | 19651622 | ||
S618 | Phosphorylation | score0 | HPRD | 19651622 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K31 | Acetylation | score1 | PhosphoSitePlus | |||
S490 | Phosphorylation | P28482 (MAPK1) | score2 | PhosphoSitePlus | 10828059 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S413 | Phosphorylation | P28482 (MAPK1) | score2 | PhosphoSitePlus | 10828059 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K42 | Ubiquitination | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
S49 | Phosphorylation | score1 | PhosphoSitePlus | |||
S51 | Phosphorylation | score1 | PhosphoSitePlus | |||
K53 | Ubiquitination | score1 | PhosphoSitePlus | |||
S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
S126 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 23826796 | |
S133 | Phosphorylation | score1 | PhosphoSitePlus | |||
K140 | Ubiquitination | score1 | PhosphoSitePlus | |||
K323 | Sumoylation | score1 | PhosphoSitePlus | |||
S651 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K42 | Ubiquitination | score1 | PhosphoSitePlus | |||
S49 | Phosphorylation | score1 | PhosphoSitePlus | |||
S51 | Phosphorylation | score1 | PhosphoSitePlus | |||
S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
S126 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 12023945 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S30 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S38 | F38 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S59 | F59 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S71 | F71 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S174 | F174 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S195 | T195 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S212 | F212 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S299 | Y299 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S301 | N301 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T317 | N317 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K323 | N323 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S348 | F348 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
K387 | N387 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S606 | F606 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |